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CLINDAMYCIN (CLEOCIN) COLITIS

LEROY E. COHEN M.D., MAJOR, MC, CHARLES J. SMITH M.D., MAJOR, MC, JAMES D. PISTER M.D., CAPTAIN, MC, and RALPH F. WELLS M.D., COLONEL, MC

Clindamycin (Cleocin) is a synthetic antibiotic used widely against gram-positive and anaerobic organisms.

In 6 patients receiving this drug, we have observed the acute onset of colitis lasting several weeks. Barium enema examinations in all patients revealed that 3 had marked mucosal abnormalities and 3 were normal. The changes included diffuse ulcerations, irregular mucosal masses, or uniform nodularity of the entire colon and rectum.

The diagnosis is established by the proctoscopic finding of unique cream-colored, plaque-like lesions superimposed on a friable or edematous mucosa.


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