SMALL BOWEL IN IMMUNOGLOBULIN DEFICIENCY SYNDROMES

¹ Clinical Professor of Radiology, Mount Sinai School of Medicine of the City University of New York, New York, New York.
² Assistant Professor of Clinical Medicine, New York University School of Medicine, New York, New York.
³ Associate Professor of Medicine, New York University School of Medicine, New York, New York.
⁴ Assistant Clinical Professor of Radiology, Mount Sinai School of Medicine of the City University of New York, New York, New York.

Recent advances in immunology have permitted recognition of a group of patients who have gastrointestinal manifestations as part of an immunoglobulin deficiency syndrome. Such immunoglobulin deficiency may be primary or may be secondary to a variety of diseases.

We have classified and described the small bowel roentgen features associated with the various immunoglobulin deficiency syndromes as follows: (1) the sprue pattern, as seen in hypogammaglobulinemic sprue and in I_gA deficient sprue; (2) multiple nodular defects, as seen in dysgammaglobulinemia; (3) inflammatory changes secondary to giardiasis, associated with immune deficiency diseases; and (4) thickening of the small intestinal folds, as seen in the plasma cell dyscrasias, lymphoma, intestinal lymphangiectasia, and amyloidosis.

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