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EFFECT OF ANGIOGRAPHIC CONTRAST MEDIA AT THE CELLULAR LEVEL IN THE BRAIN: HYPERTONIC VS. CHEMICAL ACTION

ROBERT L. WALDRON II M.D.1, RICHARD B. BRIDENBAUGH M.D.2, and EDWARD W. DEMPSEY PH.D.3

1 Associate Professor, Department of Radiology.; French Hospital, San Luis Obispo, California.
2 Instructor, Department of Radiology.
3 Chairman and Professor, Department of Anatomy.

Repeated injections of angiographic contrast media led to disruption of the endothelial barrier of the cerebral parenchymal capillaries (blood-brain barrier) experimentally by (a) promoting pinocytosis and (b) opening the tight junctions which exist between the endothelial cells.

Two mechanisms appear to be involved in this process. The hyperosmolar quality of the contrast media is responsible for the increased pinocytosis, while the chemical nature of the contrast agents used (Hypaque 50, and Conray 60), results in opening of the tight junctions.


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R. Raininko
Morphologic Endothelial Response to Meglumine Diatrizoate: An Electron- Microscopic Study
Angiology, November 1, 1981; 32(11): 733 - 741.
[Abstract] [PDF]


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