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1 Assistant Professor of Radiology, University of Pennsylvania School of Medicine.
Serial cerebral angiography was performed in dogs during momentary cardiac arrest induced by acetylcholine and in systemic hypotension induced by trimethaphan.
During momentary cardiac arrest, prolongation of the arterial phase in both intracranial and extracranial arteries was seen in the entire 6 or 12 second course of the study, while the blood pressure was at baseline level. The duration of the arterial phase was 3-4 seconds when angiography was performed during the recovery period at a mean blood pressure of 40 mm. Hg, and prolongation of the arterial phase was not observed when the study was done at the pressure of approximately 50 mm. Hg.
In systemic hypotension in the presence of continuing cardiac function, the duration of the arterial phase lasted 4-5 seconds or longer at the mean blood pressure at or below 30 mm. Hg, and prolongation of the arterial phase was not present at the pressure of 40 mm. Hg.
The duration of prolongation of the arterial phase is well correlated with the degree of hypotension at mean arterial pressures below 40 mm. Hg in both conditions.
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