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EVALUATION OF BARIUM AND GASTROGRAFIN AS CONTRAST MEDIA FOR THE DIAGNOSIS OF ESOPHAGEAL RUPTURES OR PERFORATIONS

KARIM VESSAL M.D.1, RICHARD J. MONTALI D.V.M.2, STEVEN M. LARSON M.D.3, VINCENT CHAFFEE D.V.M., PH.D.4, and A. EVERETTE JAMES JR. SC.M., M.D.5

1 Chairman, Department of Radiology, Pahlavi University Medical School, Shiraz, Iran.
2 Division of Laboratory Animal Medicine, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
3 Division of Nuclear Medicine, Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
4 Division of Laboratory Animal Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
5 Director, Laboratory for Diagnostic Radiology Research, Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

In order to study the effects of the commonly employed contrast media in the mediastinum, various combinations of contrast media and flora were instilled in the mediastinum of 30 domestic cats.

The animals were sacrificed at serial time intervals following the mediastinal injection.

These data suggest that the water soluble contrast media cause no significant histologic reaction.

Barium causes granuloma formation, but has no additional deleterious effect when mixed with normal human mouth bacterial flora of various concentrations. Because of its superior physical properties, it appears to be the contrast agent of choice in difficult clinical problems with regard to esophageal rupture or perforation.


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 Am. J. Roentgenol.Home page
J. O. Swanson, M. S. Levine, R. O. Redfern, and S. E. Rubesin
Usefulness of High-Density Barium for Detection of Leaks After Esophagogastrectomy, Total Gastrectomy, and Total Laryngectomy
Am. J. Roentgenol., August 1, 2003; 181(2): 415 - 420.
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