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MICROANGIOGRAPHY OF THE WHITE PULP OF THE SPLEEN

ALAIN E. DUBREUIL M.D., PETER G. HERMAN M.D., NICHOLAS L. TILNEY M.D., and HARRY Z. MELLINS M.D.

Based on the microangiographic study of injected and cleared rat spleen specimens, we developed a model of the microvasculature of the white pulp (Fig. 10).

The central artery and its arteriolar and capillary branches form a loosely spaced network in the periarteriolar sheath and malpighian corpuscles. From these channels, a rich and thick network of vessels is formed in the marginal zone which completely surrounds the lymphoid tissue mass of the spleen. This marginal sinus network has only poorly developed venous drainage towards the red pulp sinusoids. The microvascular morphology of the marginal sinus implies slow blood flow and this in turn could promote transvascular migration of lymphocytes. Because of the lack of venous flow from the white pulp, the only significant re-entry route to the venous circulation is the rather large periarteriolar lymphatic channels which were observed in this study.

Our model of the microcirculation of the splenic lymphoid tissues can serve as a morphologic basis of the understanding of the lymphocyte transport in the spleen.


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