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IMMUNOSUPPRESSION FOLLOWING RADIATION THERAPY FOR CARCINOMA OF THE NASOPHARYNX

WILLIAM M. WARA M.D., THEODORE L. PHILLIPS M.D., DIANE W. WARA M.D., ARTHUR J. AMMANN M.D., and VERNON SMITH M.Sc.

Eleven patients treated for nasopharyngeal carcinoma with standard radiation therapy were found to have depressed cell mediated immunity. Post-treatment their total lymphocyte count was decreased by 60 per cent. Eight of 11 patients had depressed T-cell rosettes, and 9 of 10 had abnormal lymphocyte response to PHA. Immunosuppression was probably related to irradiation of large blood volumes, irradiation of the thymus, and malnutrition.


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