SUPERIOR MESENTERIC ANGIOGRAPHY AND BLOOD FLOW FOLLOWING INTRA-ARTERIAL INJECTION OF PROSTAGLANDIN F₂

The effect of intra-arterially administered prostaglandin F₂(PGF₂) on venous demonstration in angiography of the superior mesenteric artery was compared to that of bradykinin in 10 patients, and the flow increase in this vessel following PGF₂ was measured by a dye dilution technique in another 8 patients.

The angiographic demonstration of veins was similarly improved by the 2 drugs, the effect of 60 µg. of PGF₂ being roughly equivalent to that of 10 µg. of bradykinin. The loss of arterial detail was less marked after PGF₂ which, however, had a longer duration of action. The flow studies indicated that 80 µg. of PGF₂ increased the superior mesenteric blood flow 103±16 per cent. There was no influence on blood pressure or pulse rate. The patients experienced a sensation of warmth in the abdomen for a few seconds following the injection of the drugs, but no other side effect was noted.

It is concluded that PGF₂ causes a rapid increase of the superior mesenteric blood flow in man making it suitable for pharmacoangiography of this vascular bed.

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