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American Journal of Roentgenology, Vol 129, Issue 1, 29-35
Copyright © 1977 by American Roentgen Ray Society

Articles

Calcitonin treatment in hereditary bone dysplasia with hyperphosphatasemia: a radiographic and histologic study of bone

JP Whalen, M Horwith, L Krook, I MacIntyre, E Mena, F Viteri, B Torun, and EA Nunez

Two children with bone dysplasia with hyperphosphatasemia (juvenile Paget's disease) were treated with synthetic human calcitonin. The progress of bone disease was monitored radiographically and histologically. Pretreatment radiographs showed markedly abnormal bone, characterized by lack of discrete cortex and absence of normal modeling. During treatment a discrete cortex was formed composed of compact bone, and more normal modeling occurred. This coincided with a histologic change from woven bone before treatment to a more lamellar type during treatment.
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Copyright © 1977 by the American Roentgen Ray Society.