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Articles |
Three cases of von Recklinghausen's disease (neurofibromatosis) are described, one with agenesis of a pedicle, another with multiple hypoplastic pedicles, and a third with bilateral hypoplastic pedicles producing a spondylolistesis. These peidcle deficiencies are manifestations of mesodermal dysplasia. Agenesis of the pedicle most likely represents a defect in chondrification. Hypoplasia probably represents a partial lack of development of the pedicle and the ipsilateral arch. Hypoplasia or agenesis of a pedicle should suggest the possibility of underlying neurofibromatosis.
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A. H. Crawford, S. Parikh, E. K. Schorry, and D. Von Stein The Immature Spine in Type-1 Neurofibromatosis J. Bone Joint Surg. Am., February 1, 2007; 89(suppl_1): 123 - 142. [Full Text] [PDF] |
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