Organ hyperthermia: experimental selective perfusion

The technical feasibility of selectively changing internal organ temperatures using balloon catheter perfusion was investigated. The liver or kidney temperatures were measured during the perfusion of cold or heated saline or preheated blood into the afferent vessels. Hyperthermic perfusion of the renal artery distal to an occlusion balloon catheter raised the kidney temperature to 43 degrees C. The hepatic arterial perfusion caused small changes in the liver temperature, whereas, with portal venous perfusion, the liver could be heated to 43 degrees C. Selective heating of the left hepatic lobe could be achieved by selective perfusion of the left portal vein. The potential therapeutic application of this technique is described.
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