Intravenous vs. left ventricular injection of ionic contrast material: hemodynamic implications for digital subtraction angiography

Because of the increased use of intravenous injection of contrast material for the evaluation of cardiac structure and function by digital subtraction techniques, a study was done to assess the hemodynamic effects of contrast material when used in this fashion in man. In 10 patients, with each serving as his own control, the effects of intravenous and intraventricular injections of sodium meglumine diatrizoate (Renografin 76) in the same dose were compared. There was no difference between these two methods with respect to changes in pulmonary wedge pressures, systemic pressures, and pulmonary vascular resistance. The elevation of mean pulmonary artery and right atrial pressure was greater after the intraventricular injection (p less than 0.05). The elevated cardiac output and systemic vascular resistance returned to control values somewhat more quickly after the intravenous injection (p less than 0.001 and p less than 0.05, respectively); and the increase in cardiac output was greater after the intravenous injection at 1 min (p less than 0.05), but less than after the intraventricular injection at 2 min (p less than 0.05). Despite the detection of these statistically significant differences, the magnitude and timing of these differences are too small to justify the notion that imaging by intravenous injections of standard ionic contrast media provides any substantial hemodynamic benefits or decreased risk to the patient.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. B. Pitton, G. Kemmerich, S. Herber, E. Mayer, M. Thelen, and C. Duber Hemodynamic effects of monomeric nonionic contrast media in pulmonary angiography in chronic thromboembolic pulmonary hypertension. Am. J. Roentgenol., July 1, 2006; 187(1): 128 - 134. [Abstract] [Full Text] [PDF]

				L. V. Hofmann, D. S. Lee, A. Gupta, A. Arepally, S. Sood, R. Girgis, and J. Eng Safety and Hemodynamic Effects of Pulmonary Angiography in Patients with Pulmonary Hypertension: 10-Year Single-Center Experience Am. J. Roentgenol., September 1, 2004; 183(3): 779 - 785. [Abstract] [Full Text] [PDF]

				M. B. Pitton, C. Duber, E. Mayer, and M. Thelen Hemodynamic Effects of Nonionic Contrast Bolus Injection and Oxygen Inhalation During Pulmonary Angiography in Patients With Chronic Major-Vessel Thromboembolic Pulmonary Hypertension Circulation, November 15, 1996; 94(10): 2485 - 2491. [Abstract] [Full Text]