Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex

Gadolinium (Gd)-DTPA complex was assessed as a nuclear magnetic resonance (NMR) contrast-enhancing agent by experimentally imaging normal and diseased animals. After intravenous injection, Gd-DTPA, a strongly paramagnetic complex by virtue of unpaired electrons, was rapidly excreted into the urine of rats, producing an easily observable contrast enhancement on NMR images in kidney parenchyma and urine. Spin-echo intensity of urine within the renal pelvis increased from 2263 to 4414 units; intensity of renal parenchyma increased from 2901 to 3893 after administration of 0.1 mmol/kg Gd-DTPA. Sterile soft-tissue abscesses demonstrated an obvious rim pattern of enhancement. A focus of radiation-induced brain damage in a canine model was only faintly detectable on spin-echo NMR images before contrast administration; after 0.5 mmol/kg Gd-DTPA administration, the lesion intensity increased from 3867 to 5590. In comparison, the normal brain with an intact blood-brain barrier remained unchanged in NMR characterization. Gd-DTPA is a promising new NMR contrast enhancer for the clinical assessment of renal function, of inflammatory lesions, and of focal disruption of the blood-brain barrier.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. H. Wang, P. Q. Min, P. J. Wang, W. X. Cheng, X. H. Zhang, Y. Wang, X. H. Zhao, and X. Q. Mao Dynamic CT Evaluation of Tumor Vascularity in Renal Cell Carcinoma. Am. J. Roentgenol., May 1, 2006; 186(5): 1423 - 1430. [Abstract] [Full Text] [PDF]

				P. Hunold, T. Schlosser, F. M. Vogt, H. Eggebrecht, A. Schmermund, O. Bruder, W. O. Schuler, and J. Barkhausen Myocardial Late Enhancement in Contrast-Enhanced Cardiac MRI: Distinction Between Infarction Scar and Non-Infarction-Related Disease Am. J. Roentgenol., May 1, 2005; 184(5): 1420 - 1426. [Abstract] [Full Text] [PDF]

				A. R. Margulis, Y. H. Auh, and M. Gagner Oral Use of Gadopentetate Dimeglumine for Anastomotic Leak in Patients with Iodine Sensitivity Radiology, September 1, 2004; 232(3): 937 - 937. [Full Text] [PDF]

				H. S. Teh, E. S. Ang, W. C. Wong, S. B. Tan, A. G. S. Tan, S. M. Chng, M. B. K. Lin, and J. S. K. Goh MR Renography Using a Dynamic Gradient-Echo Sequence and Low-Dose Gadopentetate Dimeglumine as an Alternative to Radionuclide Renography Am. J. Roentgenol., August 1, 2003; 181(2): 441 - 450. [Abstract] [Full Text] [PDF]

				W. K. Rohrschneider, S. Haufe, M. Wiesel, B. Tonshoff, R. Wunsch, K. Darge, J. H. Clorius, and J. Troger Functional and Morphologic Evaluation of Congenital Urinary Tract Dilatation by Using Combined Static-Dynamic MR Urography: Findings in Kidneys with a Single Collecting System Radiology, September 1, 2002; 224(3): 683 - 694. [Abstract] [Full Text] [PDF]

				A. A. Tzika, M. K. Zarifi, L. Goumnerova, L. G. Astrakas, D. Zurakowski, T. Young-Poussaint, D. C. Anthony, R. M. Scott, and P. McL. Black Neuroimaging in Pediatric Brain Tumors: Gd-DTPA-enhanced, Hemodynamic, and Diffusion MR Imaging Compared with MR Spectroscopic Imaging AJNR Am. J. Neuroradiol., February 1, 2002; 23(2): 322 - 333. [Abstract] [Full Text] [PDF]

				C. Klein, S. G. Nekolla, F. M. Bengel, M. Momose, A. Sammer, F. Haas, B. Schnackenburg, W. Delius, H. Mudra, D. Wolfram, et al. Assessment of Myocardial Viability With Contrast-Enhanced Magnetic Resonance Imaging: Comparison With Positron Emission Tomography Circulation, January 15, 2002; 105(2): 162 - 167. [Abstract] [Full Text] [PDF]

				E. Warner, D. B. Plewes, R. S. Shumak, G. C. Catzavelos, L. S. Di Prospero, M. J. Yaffe, V. Goel, E. Ramsay, P. L. Chart, D. E.C. Cole, et al. Comparison of Breast Magnetic Resonance Imaging, Mammography, and Ultrasound for Surveillance of Women at High Risk for Hereditary Breast Cancer J. Clin. Oncol., August 1, 2001; 19(15): 3524 - 3531. [Abstract] [Full Text] [PDF]

				G. Sersa, M. Krzic, M. Sentjurc, T. Ivanusa, K. Beravs, M. Cemazar, M. Auersperg, and H. M. Swartz Reduced Tumor Oxygenation by Treatment with Vinblastine Cancer Res., May 1, 2001; 61(10): 4266 - 4271. [Abstract] [Full Text]

				A. C. Mamourian, P. Jack Hoopes, and L. D. Lewis Visualization of Intravenously Administered Contrast Material in the CSF on Fluid-AttenuatedInversion-Recovery MR Images: An In Vitro and Animal-Model Investigation AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 105 - 111. [Abstract] [Full Text] [PDF]

				E. A. Knopp, S. Cha, G. Johnson, A. Mazumdar, J. G. Golfinos, D. Zagzag, D. C. Miller, P. J. Kelly, and I. I. Kricheff Glial Neoplasms: Dynamic Contrast-enhanced T2*-weighted MR Imaging Radiology, June 1, 1999; 211(3): 791 - 798. [Abstract] [Full Text]

				K. Ramani, R. M. Judd, T. A. Holly, T. B. Parrish, V. H. Rigolin, M. A. Parker, C. Callahan, S. W. Fitzgerald, R. O. Bonow, and F. J. Klocke Contrast Magnetic Resonance Imaging in the Assessment of Myocardial Viability in Patients With Stable Coronary Artery Disease and Left Ventricular Dysfunction Circulation, December 15, 1998; 98(24): 2687 - 2694. [Abstract] [Full Text] [PDF]

				M. G. Friedrich, O. Strohm, J. Schulz-Menger, H. Marciniak, F. C. Luft, and R. Dietz Contrast Media–Enhanced Magnetic Resonance Imaging Visualizes Myocardial Changes in the Course of Viral Myocarditis Circulation, May 19, 1998; 97(18): 1802 - 1809. [Abstract] [Full Text] [PDF]

				H. Matsuoka, M. Hamada, T. Honda, H. Kawakami, M. Abe, Y. Shigematsu, T. Sumimoto, and K. Hiwada Morphologic and Histologic Characterization of Cardiac Myxomas by Magnetic Resonance Imaging Angiology, July 1, 1996; 47(7): 693 - 698. [Abstract] [PDF]

				E. E. van der Wall, H. W. Vliegen, A. de Roos, and A. V.G. Bruschke Magnetic Resonance Imaging in Coronary Artery Disease Circulation, November 1, 1995; 92(9): 2723 - 2739. [Abstract] [Full Text]