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American Journal of Roentgenology, Vol 143, Issue 2, 235-243
Copyright © 1984 by American Roentgen Ray Society

Articles

CT of the liver and spleen with EOE-13: review of 225 examinations

DL Miller, M Vermess, JL Doppman, RM Simon, PH Sugarbaker, TJ O'Leary, G Grimes, DG Chatterji, and M Willis

EOE-13 is an experimental liver-spleen-specific computed tomographic (CT) contrast agent developed at the National Institutes of Health. Experience with this agent in 225 clinical examinations is described. On average, use of EOE-13 increases the attenuation of normal liver by 32.5 H and that of normal spleen by 52.3 H. Tumors in these organs increase only 2.6 H, making them more easily detectable. Most of the iodine in EOE-13 appears to clear from the liver and spleen by 24 hr after injection. No deaths or permanent morbidity have been observed. The complication rate is 3.6%. EOE-13 is valuable for the detection of hepatic and splenic tumors.
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Am. J. Roentgenol., March 1, 2000; 174(3): 691 - 698.
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