MRI in the detection of malignant infiltration of bone marrow

Magnetic resonance imaging (MRI) at 0.35 T with a superconductive magnet was performed on 80 patients with known or suspected malignant disease of the bone marrow. The group comprised 50 patients with known primary malignancy and 30 with known multiple myeloma. The MRI scan was correlated with plain films and radionuclide bone scans. In 40 patients with suspected metastatic disease, areas of decreased signal intensity on T1-weighted spin-echo images were observed. Ten patients had no MRI evidence of metastasis, and the abnormalities suspected on bone scanning were shown to be due to other causes. All the myeloma patients had abnormalities demonstrated by MRI. This was significant, since most had normal bone scans. All diagnoses were confirmed by needle biopsy. MRI was shown to be a sensitive method of detecting areas of malignancy within the bone marrow toward which biopsy could be directed.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. D. Cohen MRI and the Detection of Bone Marrow Tumor Am. J. Roentgenol., January 1, 2008; 190(1): W75 - W75. [Full Text] [PDF]

				D.S. McMenamin, S.L. Stuckey, and G.J. Potgieter T1 Hyperintense Vertebral Column Melanoma Metastases AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1817 - 1818. [Abstract] [Full Text] [PDF]

				F. E. Lecouvet, D. Geukens, A. Stainier, F. Jamar, J. Jamart, B. J. d'Othee, P. Therasse, B. V. Berg, and B. Tombal Magnetic Resonance Imaging of the Axial Skeleton for Detecting Bone Metastases in Patients With High-Risk Prostate Cancer: Diagnostic and Cost-Effectiveness and Comparison With Current Detection Strategies J. Clin. Oncol., August 1, 2007; 25(22): 3281 - 3287. [Abstract] [Full Text] [PDF]

				L. S. Steinbach "MRI in the Detection of Malignant Infiltration of Bone Marrow"--A Commentary Am. J. Roentgenol., June 1, 2007; 188(6): 1443 - 1445. [Full Text] [PDF]

				A.Y. Oner, T. Tali, F. Celikyay, A. Celik, and P. Le Roux Diffusion-Weighted Imaging of the Spine with a Non-Carr-Purcell-Meiboom-Gill Single-Shot Fast Spin-Echo Sequence: Initial Experience AJNR Am. J. Neuroradiol., March 1, 2007; 28(3): 575 - 580. [Abstract] [Full Text] [PDF]

				S. D. O'Connor, J. Yao, and R. M. Summers Lytic Metastases in Thoracolumbar Spine: Computer-aided Detection at CT--Preliminary Study Radiology, March 1, 2007; 242(3): 811 - 816. [Abstract] [Full Text] [PDF]

				H. M. Barragan-Campos, J.-N. Vallee, D. Lo, E. Cormier, B. Jean, M. Rose, P. Astagneau, and J. Chiras Percutaneous Vertebroplasty for Spinal Metastases: Complications Radiology, January 1, 2006; 238(1): 354 - 362. [Abstract] [Full Text] [PDF]

				T. Hamaoka, J. E. Madewell, D. A. Podoloff, G. N. Hortobagyi, and N. T. Ueno Bone Imaging in Metastatic Breast Cancer J. Clin. Oncol., July 15, 2004; 22(14): 2942 - 2953. [Abstract] [Full Text] [PDF]

				A. M. Herneth, M. O. Philipp, J. Naude, M. Funovics, R. R. Beichel, R. Bammer, and H. Imhof Vertebral Metastases: Assessment with Apparent Diffusion Coefficient Radiology, December 1, 2002; 225(3): 889 - 894. [Abstract] [Full Text] [PDF]

				R. A. Koenigsberg, P. Black, S. H. Faro, and J. Rykken Lumbar Disk Pseudotumor: An Unusual Presentation of Lumbar Spinal Fracture and Stenosis AJNR Am. J. Neuroradiol., November 1, 2002; 23(10): 1662 - 1664. [Abstract] [Full Text] [PDF]

				H. P. Ledermann, W. B. Morrison, and M. E. Schweitzer MR Image Analysis of Pedal Osteomyelitis: Distribution, Patterns of Spread, and Frequency of Associated Ulceration and Septic Arthritis Radiology, June 1, 2002; 223(3): 747 - 755. [Abstract] [Full Text] [PDF]

				L. A. Loevner, J. D. Tobey, D. M. Yousem, A. I. Sonners, and W. C. Hsu MR Imaging Characteristics of Cranial Bone Marrow in Adult Patients with Underlying Systemic Disorders Compared with Healthy Control Subjects AJNR Am. J. Neuroradiol., February 1, 2002; 23(2): 248 - 254. [Abstract] [Full Text] [PDF]

				T. Taoka, N. A. Mayr, H. J. Lee, W. T. C. Yuh, T. M. Simonson, K. Rezai, and K. S. Berbaum Factors Influencing Visualization of Vertebral Metastases on MR Imaging Versus Bone Scintigraphy Am. J. Roentgenol., June 1, 2001; 176(6): 1525 - 1530. [Abstract] [Full Text] [PDF]

				A. Stäbler, A. B. Doma, A. Baur, A. Krüger, and M. F. Reiser Reactive Bone Marrow Changes in Infectious Spondylitis: Quantitative Assessment with MR Imaging Radiology, December 1, 2000; 217(3): 863 - 868. [Abstract] [Full Text]

				M. Castillo, A. Arbelaez, J. K. Smith, and L. L. Fisher Diffusion-weighted MR Imaging Offers No Advantage over Routine Noncontrast MR Imaging in the Detection of Vertebral Metastases AJNR Am. J. Neuroradiol., May 1, 2000; 21(5): 948 - 953. [Abstract] [Full Text]

				S. Takagi, O. Tanaka, H. Origasa, and Y. Miura Prognostic Significance of Magnetic Resonance Imaging of Femoral Marrow in Patients With Myelodysplastic Syndromes J. Clin. Oncol., January 1, 1999; 17(1): 277 - 277. [Abstract] [Full Text] [PDF]

				L. A. Moulopoulos and M. A. Dimopoulos Magnetic Resonance Imaging of the Bone Marrow in Hematologic Malignancies Blood, September 15, 1997; 90(6): 2127 - 2147. [Full Text] [PDF]

				S. Tsunoda, S. Takagi, O. Tanaka, and Y. Miura Clinical and Prognostic Significance of Femoral Marrow Magnetic Resonance Imaging in Patients With Malignant Lymphoma Blood, January 1, 1997; 89(1): 286 - 290. [Abstract] [Full Text] [PDF]

				M. Castillo, J. Tehranzadeh, and G. Morillo Atypical healed stress fracture of the fibula masquerading as chronic osteomyelitis: A case report of magnetic resonance distinction Am. J. Sports Med., March 1, 1988; 16(2): 185 - 188. [PDF]