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American Journal of Roentgenology, Vol 147, Issue 3, 627-631
Copyright © 1986 by American Roentgen Ray Society

Articles

Histologic analysis of tissue response to bucrylate-pantopaque mixture

LD Cromwell, PC Freeny, CW Kerber, LL Kunz, AB Harris, and CM Shaw

A toxicologic-pathologic study of isobutyl-2-cyanoacrylate (Bucrylate) was carried out first in dogs and then in humans whose arteriovenous malformations were infused with this embolic agent. The canine specimens obtained at 7, 18, 28, and 147 days after embolization showed the development of a mild histiocytic giant cell reaction, which evolved to end-state sclerotic arteritis. The response was confined to the vessels and did not involve contiguous parenchymal tissues. Ten human specimens, obtained from 1 hr to 7 years after treatment, showed a similar bland reaction with no evidence of suppuration or premalignant changes.
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Copyright © 1986 by the American Roentgen Ray Society.