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American Journal of Roentgenology, Vol 153, Issue 6, 1283-1288
Copyright © 1989 by American Roentgen Ray Society

Articles

MR findings in methotrexate-induced CNS abnormalities

F Ebner, G Ranner, I Slavc, C Urban, R Kleinert, H Radner, R Einspieler, and E Justich

Department of Radiology, Karl-Franzens-University Graz, Medical School, Austria.

MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate. MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction. Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy. MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.
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