American Journal of Roentgenology, Vol 156, 1191-1194, Copyright © 1991 by American Roentgen Ray Society
Clinical stage I carcinoma of the cervix: value of MR imaging in determining degree of invasiveness
HH Lien, V Blomlie, K Kjorstad, V Abeler and O Kaalhus
Department of Diagnostic Radiology, Norwegian Radium Hospital, Oslo.
The depth of tumor invasion measured at histologic examination is the most
important prognostic factor in early-stage carcinoma of the uterine cervix.
The ability of MR to estimate the depth of tumor invasion was studied in 47
patients who subsequently underwent radical hysterectomy. In two patients,
MR failed to detect tumors with infiltration depths of 2 and 4 mm. The
maximum sagittal tumor length along the axis of the cervix (D) and the
maximum tumor area on sagittal (S) and axial (A) images were measured with
MR. The depth of tumor infiltration determined histologically (I)
correlated with the degree of infiltration noted on MR images. The
univariate correlation coefficients for log I vs log D, log S, and log A
were .87, .84, and .77, respectively. By stepwise inclusion of the
variables in a multivariate analysis, the contributions to the coefficient
of determination from including log S and log A after log D were less than
1%. The regression analysis showed that the best estimate for the depth of
invasion was close to half of the sagittal tumor length measured on MR, I =
D/2. Our experience shows that MR is valuable in determining the degree of
invasiveness in clinical stage I tumors.
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