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American Journal of Roentgenology, Vol 157, 697-701, Copyright © 1991 by American Roentgen Ray Society

ARTICLES

Paraquat poisoning: findings on chest radiography and CT in 42 patients

JG Im, KS Lee, MC Han, SJ Kim and IO Kim
Department of Diagnostic Radiology, Seoul National University Hospital, Korea.

The purpose of this study is to describe the radiologic manifestations of paraquat-induced pulmonary damage, with special emphasis on the sequential changes seen with this condition. Paraquat is a herbicide that has toxic effects on the lungs, liver, and kidneys. Progressive respiratory failure is a frequent cause of death. We analyzed retrospectively 42 patients with a history of paraquat ingestion and abnormal findings on chest radiographs. Radiographic changes during the first week after ingestion included diffuse consolidation (26/39), pneumomediastinum with or without pneumothorax (15/39), and cardiomegaly with widening of the superior mediastinum (8/39). Small cystic and linear shadows began to appear at the end of the first week and were the preponderant parenchymal abnormality after 2-4 weeks. Focal honeycombing was the major parenchymal abnormality after 4 weeks. High-resolution CT of the lung 9 months after paraquat exposure revealed localized fibrosis containing small cysts. Our study shows that the pulmonary manifestations of paraquat poisoning begin with air- space consolidation, which then leads to end-stage lung.
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Copyright © 1991 by the American Roentgen Ray Society.