AJR ARRS Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tien, R. D.
Right arrow Articles by MacFall, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tien, R. D.
Right arrow Articles by MacFall, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

American Journal of Roentgenology, Vol 162, 671-677, Copyright © 1994 by American Roentgen Ray Society

ARTICLES

MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences

RD Tien, GJ Felsberg, H Friedman, M Brown and J MacFall
Department of Radiology, Duke University Medical Center, Durham, NC 27710.

OBJECTIVE. The purpose of this study was to evaluate the usefulness of diffusion-weighted echoplanar MR imaging in the examination of high- grade brain gliomas compared with that of conventional spin-echo (SE) or fast spin-echo (FSE) MR imaging. We hypothesize that diffusion- weighted MR imaging may enable us to differentiate various tumor components on the basis of differences in the diffusion of water. SUBJECTS AND METHODS. Conventional SE and FSE MR images were obtained in 10 patients with high-grade brain glioma. Diffusion-weighted echoplanar MR images were obtained with a head gradient coil capable of providing diffusion-weighted imaging along the cephalocaudal axis. Using SE and FSE MR images as a baseline, we evaluated the diffusion- weighted MR images for usefulness in distinguishing tumor components on the basis of differences in diffusion. RESULTS. Areas of tumor that showed significant enhancement on T1-weighted SE MR images obtained after injection of contrast material were markedly hyperintense on diffusion-weighted images and had a lower apparent diffusion coefficient (ADC) than the ADCs for nonenhancing tumor and peritumoral edema. Cystic or necrotic portions of tumor showed the most signal suppression on diffusion-weighted images and were associated with the highest ADCs. On T2-weighted FSE MR images, areas of hyperintensity observed in white matter oriented parallel to the direction of the diffusion gradient could be differentiated into two patterns on the basis of findings on diffusion-weighted images: areas that showed marked signal suppression with a higher ADC, most likely representing areas of predominantly peritumoral edema, and areas that showed a lesser degree of signal suppression with similar but slightly lower ADCs than those of edema, most likely representing areas of predominantly nonenhancing tumor. CONCLUSION. Diffusion-weighted echoplanar MR imaging is a useful technique for examining high-grade cerebral gliomas. It enabled us to differentiate various components of the tumor (e.g., enhancing, nonenhancing, cystic, or necrotic) and to distinguish areas of predominantly nonenhancing tumor from areas of predominantly peritumoral edema when the abnormality was located in the white matter aligned in the direction of the diffusion-weighted gradient. Diffusion-weighted echoplanar MR imaging appears to be a powerful tool in the characterization of brain neoplasms.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
D. C. Colvin, T. E. Yankeelov, M. D. Does, Z. Yue, C. Quarles, and J. C. Gore
New Insights into Tumor Microstructure Using Temporal Diffusion Spectroscopy
Cancer Res., July 15, 2008; 68(14): 5941 - 5947.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
P. Mukherjee, J.I. Berman, S.W. Chung, C.P. Hess, and R.G. Henry
Diffusion Tensor MR Imaging and Fiber Tractography: Theoretic Underpinnings
AJNR Am. J. Neuroradiol., April 1, 2008; 29(4): 632 - 641.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
P. G. P. Nucifora, R. Verma, S.-K. Lee, and E. R. Melhem
Diffusion-Tensor MR Imaging and Tractography: Exploring Brain Microstructure and Connectivity
Radiology, November 1, 2007; 245(2): 367 - 384.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
H.S. Kim and S.Y. Kim
A Prospective Study on the Added Value of Pulsed Arterial Spin-Labeling and Apparent Diffusion Coefficients in the Grading of Gliomas
AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1693 - 1699.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C.R. Habermann, P. Gossrau, H. Kooijman, J. Graessner, M.C. Cramer, M.G. Kaul, F. Reitmeier, M. Jaehne, and G. Adam
Monitoring of Gustatory Stimulation of Salivary Glands by Diffusion-Weighted MR Imaging: Comparison of 1.5T and 3T
AJNR Am. J. Neuroradiol., September 1, 2007; 28(8): 1547 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
R. M. Kwee and T. C. Kwee
Virchow-Robin Spaces at MR Imaging
RadioGraphics, July 1, 2007; 27(4): 1071 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Matoba, H. Tonami, T. Kondou, H. Yokota, K. Higashi, H. Toga, and T. Sakuma
Lung Carcinoma: Diffusion-weighted MR Imaging--Preliminary Evaluation with Apparent Diffusion Coefficient
Radiology, May 1, 2007; 243(2): 570 - 577.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
Y. J. Choi, J. K. Kim, N. Kim, K. W. Kim, E. K. Choi, and K.-S. Cho
Functional MR Imaging of Prostate Cancer
RadioGraphics, January 1, 2007; 27(1): 63 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
G G Fan, Q L Deng, Z H Wu, and Q Y Guo
Usefulness of diffusion/perfusion-weighted MRI in patients with non-enhancing supratentorial brain gliomas: a valuable tool to predict tumour grading?
Br. J. Radiol., August 1, 2006; 79(944): 652 - 658.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
Z. Rumboldt, D.L.A. Camacho, D. Lake, C.T. Welsh, and M. Castillo
Apparent Diffusion Coefficients for Differentiation of Cerebellar Tumors in Children
AJNR Am. J. Neuroradiol., June 1, 2006; 27(6): 1362 - 1369.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K.J. Helton, N.S. Phillips, R.B. Khan, F.A. Boop, R.A. Sanford, P. Zou, C.S. Li, J.W. Langston, and R.J. Ogg
Diffusion tensor imaging of tract involvement in children with pontine tumors.
AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 786 - 793.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. S. Donaldson, F. Laningham, and P. G. Fisher
Advances Toward an Understanding of Brainstem Gliomas
J. Clin. Oncol., March 10, 2006; 24(8): 1266 - 1272.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
Y.M. Tang, S. Ngai, and S. Stuckey
The Solitary Enhancing Cerebral Lesion: Can FLAIR Aid the Differentiation between Glioma and Metastasis?
AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 609 - 611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C. Asao, Y. Korogi, M. Kitajima, T. Hirai, Y. Baba, K. Makino, M. Kochi, S. Morishita, and Y. Yamashita
Diffusion-Weighted Imaging of Radiation-Induced Brain Injury for Differentiation from Tumor Recurrence
AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1455 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. M. Provenzale, P. McGraw, P. Mhatre, A. C. Guo, and D. Delong
Peritumoral Brain Regions in Gliomas and Meningiomas: Investigation with Isotropic Diffusion-weighted MR Imaging and Diffusion-Tensor MR Imaging
Radiology, August 1, 2004; 232(2): 451 - 460.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Lu, D. Ahn, G. Johnson, M. Law, D. Zagzag, and R. I. Grossman
Diffusion-Tensor MR Imaging of Intracranial Neoplasia and Associated Peritumoral Edema: Introduction of the Tumor Infiltration Index
Radiology, July 1, 2004; 232(1): 221 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
K J Ahn, J W Lee, S T Hahn, D W Yang, P S Kim, H J Kim, and C C Kim
Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity
Br. J. Radiol., December 1, 2003; 76(912): 916 - 919.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. J. Nelson
Multivoxel Magnetic Resonance Spectroscopy of Brain Tumors
Mol. Cancer Ther., May 1, 2003; 2(5): 497 - 507.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
N. Bulakbasi, M. Kocaoglu, F. Ors, C. Tayfun, and T. Ucoz
Combination of Single-Voxel Proton MR Spectroscopy and Apparent Diffusion Coefficient Calculation in the Evaluation of Common Brain Tumors
AJNR Am. J. Neuroradiol., February 1, 2003; 24(2): 225 - 233.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
T. W. Stadnik, P. Demaerel, R. R Luypaert, C. Chaskis, K. L. Van Rompaey, A. Michotte, and M. J. Osteaux
Imaging Tutorial: Differential Diagnosis of Bright Lesions on Diffusion-weighted MR Images
RadioGraphics, January 1, 2003; 23(1): e7 - e7.
[Abstract] [Full Text]

Home page
 RadiologyHome page
A. C. Guo, T. J. Cummings, R. C. Dash, and J. M. Provenzale
Lymphomas and High-Grade Astrocytomas: Comparison of Water Diffusibility and Histologic Characteristics
Radiology, July 1, 2002; 224(1): 177 - 183.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
A. Rovira, I. Pericot, J. Alonso, J. Rio, E. Grive, and X. Montalban
Serial Diffusion-Weighted MR Imaging and Proton MR Spectroscopy of Acute Large Demyelinating Brain Lesions: Case Report
AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 989 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. Y. Yoo, K.-H. Chang, I. C. Song, M. H. Han, B. J. Kwon, S. H. Lee, I. K. Yu, and C.-K. Chun
Apparent Diffusion Coefficient Value of the Hippocampus in Patients with Hippocampal Sclerosis and in Healthy Volunteers
AJNR Am. J. Neuroradiol., May 1, 2002; 23(5): 809 - 812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. Sinha, M. E. Bastin, I. R. Whittle, and J. M. Wardlaw
Diffusion Tensor MR Imaging of High-Grade Cerebral Gliomas
AJNR Am. J. Neuroradiol., April 1, 2002; 23(4): 520 - 527.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
G. A. Tung, P. Evangelista, J. M. Rogg, and J. A. Duncan III
Diffusion-Weighted MR Imaging of Rim-Enhancing Brain Masses: Is Markedly Decreased Water Diffusion Specific For Brain Abscess?
Am. J. Roentgenol., September 1, 2001; 177(3): 709 - 712.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. Wang, S. Takashima, F. Takayama, S. Kawakami, A. Saito, T. Matsushita, M. Momose, and T. Ishiyama
Head and Neck Lesions: Characterization with Diffusion-weighted Echo-planar MR Imaging
Radiology, September 1, 2001; 220(3): 621 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
K. M. Gauvain, R. C. McKinstry, P. Mukherjee, A. Perry, J. J. Neil, B. A. Kaufman, and R. J. Hayashi
Evaluating Pediatric Brain Tumor Cellularity with Diffusion-Tensor Imaging
Am. J. Roentgenol., August 1, 2001; 177(2): 449 - 454.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
R. D. Zimmerman
Is There a Role for Diffusion-weighted Imaging in Patients with Brain Tumors or Is the "Bloom off the Rose"?
AJNR Am. J. Neuroradiol., June 1, 2001; 22(6): 1013 - 1019.
[Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K. Kono, Y. Inoue, K. Nakayama, M. Shakudo, M. Morino, K. Ohata, K. Wakasa, and R. Yamada
The Role of Diffusion-weighted Imaging in Patients with Brain Tumors
AJNR Am. J. Neuroradiol., June 1, 2001; 22(6): 1081 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. Chen, F. Ikawa, K. Kurisu, K. Arita, J. Takaba, and Y. Kanou
Quantitative MR Evaluation of Intracranial Epidermoid Tumors by Fast Fluid-attenuated Inversion Recovery Imaging and Echo-planar Diffusion-weighted Imaging
AJNR Am. J. Neuroradiol., June 1, 2001; 22(6): 1089 - 1096.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. E. Maier, P. Bogner, G. Bajzik, H. Mamata, Y. Mamata, I. Repa, F. A. Jolesz, and R. V. Mulkern
Normal Brain and Brain Tumor: Multicomponent Apparent Diffusion Coefficient Line Scan Imaging
Radiology, June 1, 2001; 219(3): 842 - 849.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
T. W. Stadnik, C. Chaskis, A. Michotte, W. M. Shabana, K. van Rompaey, R. Luypaert, L. Budinsky, V. Jellus, and M. Osteaux
Diffusion-weighted MR Imaging of Intracerebral Masses: Comparison with Conventional MR Imaging and Histologic Findings
AJNR Am. J. Neuroradiol., May 1, 2001; 22(5): 969 - 976.
[Abstract] [Full Text]

Home page
 BrainHome page
S. H. Eriksson, F. J. Rugg-Gunn, M. R. Symms, G. J. Barker, and J. S. Duncan
Diffusion tensor imaging in patients with epilepsy and malformations of cortical development
Brain, March 1, 2001; 124(3): 617 - 626.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Castillo, J. K. Smith, L. Kwock, and K. Wilber
Apparent Diffusion Coefficients in the Evaluation of High-grade Cerebral Gliomas
AJNR Am. J. Neuroradiol., January 1, 2001; 22(1): 60 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C. G. Filippi, M. A. Edgar, A. M. Ulu, J. C. Prowda, L. A. Heier, and R. D. Zimmerman
Appearance of Meningiomas on Diffusion-weighted Images: Correlating Diffusion Constants with Histopathologic Findings
AJNR Am. J. Neuroradiol., January 1, 2001; 22(1): 65 - 72.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. R. Meyer, A. Gutierrez, B. Mock, D. Hebron, J. M. Prager, M. T. Gorey, and D. Homer
High-b-value Diffusion-weighted MR Imaging of Suspected Brain Infarction
AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1821 - 1829.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
P. W. Schaefer, P. E. Grant, and R. G. Gonzalez
Diffusion-weighted MR Imaging of the Brain
Radiology, November 1, 2000; 217(2): 331 - 345.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
S. W. Atlas, P. DuBois, M. B. Singer, and D. Lu
Diffusion Measurements in Intracranial Hematomas: Implications for MR Imaging of Acute Stroke
AJNR Am. J. Neuroradiol., July 1, 2000; 21(7): 1190 - 1194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
B. Desprechins, T. Stadnik, G. Koerts, W. Shabana, C. Breucq, and M. Osteaux
Use of Diffusion-Weighted MR Imaging in Differential Diagnosis Between Intracerebral Necrotic Tumors and Cerebral Abscesses
AJNR Am. J. Neuroradiol., August 1, 1999; 20(7): 1252 - 1257.
[Abstract] [Full Text]

Home page
 StrokeHome page
P. W. Schaefer, F. S. Buonanno, R. G. Gonzalez, and L. H. Schwamm
Diffusion-Weighted Imaging Discriminates Between Cytotoxic and Vasogenic Edema in a Patient With Eclampsia
Stroke, May 1, 1997; 28(5): 1082 - 1085.
[Abstract] [Full Text]

Home page
 RadiologyHome page
N. Yoshino, I. Yamada, N. Ohbayashi, E. Honda, M. Ida, T. Kurabayashi, K. Maruyama, and T. Sasaki
Salivary Glands and Lesions: Evaluation of Apparent Diffusion Coefficients with Split-Echo Diffusion-weighted MR Imaging—Initial Results
Radiology, December 1, 2001; 221(3): 837 - 842.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the American Roentgen Ray Society.