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American Journal of Roentgenology, Vol 170, 499-502, Copyright © 1998 by American Roentgen Ray Society

ARTICLES

Dural sinus thrombosis associated with activated protein C resistance: MR imaging findings and proband identification

JM Provenzale, DP Barboriak and TL Ortel
Department of Radiology, Duke University Medical Center, Durham, NC 27710-3808, USA.

OBJECTIVE: The purpose of this study was to report the association of dural sinus thrombosis with a hypercoagulable state associated with activated protein C resistance. CONCLUSION: In our small study population, hemorrhagic venous infarction was common (three of four patients) among patients with dural sinus thrombosis and activated protein C resistance. Four of five patients with dural sinus thrombosis had positive tests for activated protein C resistance. This finding, in conjunction with data from other studies, suggests that patients with dural sinus thrombosis may need to be studied for the presence of activated protein C resistance. A positive finding for activated protein C resistance can be important not only in helping to explain the cause of thrombosis in affected individuals but also in identifying families at risk for thrombosis.
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