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American Journal of Roentgenology, Vol 172, 735-739, Copyright © 1999 by American Roentgen Ray Society

ARTICLES

Pulmonary injury from proton and conventional radiotherapy as revealed by CT

DA Bush, RD Dunbar, R Bonnet, JD Slater, GA Cheek and JM Slater
Department of Radiation Medicine, Loma Linda University Medical Center, CA 92354, USA.

OBJECTIVE: Although radiation therapy is used in early-stage inoperable lung cancer, it often results in injury to functional lung tissue. A study was undertaken to determine the frequency and severity of pulmonary injury revealed by CT in patients who had undergone conformal proton (to a limited volume) radiation therapy. We compared these findings with those from a group of patients who had undergone a combination of photon and conformal proton (to a larger volume) radiation therapy. CONCLUSION: Proton radiation therapy was associated with a lower frequency of pulmonary injury than the combined regimen. Injury correlated well with the volume of normal lung that was irradiated. Conformal proton radiation therapy appears to be able to reduce the incidence and severity of pulmonary injury revealed by CT.
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This article has been cited by other articles:


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R. B. Bonnet, D. Bush, G. A. Cheek, J. D. Slater, D. Panossian, C. Franke, and J. M. Slater
Effects of Proton and Combined Proton/Photon Beam Radiation on Pulmonary Function in Patients With Resectable but Medically Inoperable Non-small Cell Lung Cancer
Chest, December 1, 2001; 120(6): 1803 - 1810.
[Abstract] [Full Text] [PDF]

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D. A. Bush, J. D. Slater, R. Bonnet, G. A. Cheek, R. D. Dunbar, M. Moyers, and J. M. Slater
Proton-Beam Radiotherapy for Early-Stage Lung Cancer
Chest, November 1, 1999; 116(5): 1313 - 1319.
[Abstract] [Full Text] [PDF]


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Copyright © 1999 by the American Roentgen Ray Society.