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American Journal of Roentgenology, Vol 173, 1557-1563, Copyright © 1999 by American Roentgen Ray Society

ARTICLES

Recanalization of thrombosed superficial femoral arteries with a hydraulic thrombectomy catheter in a canine model

Z Qian, M Wholey, H Ferral, M Maynar, D Postoak, J Hamide, WP Newman 3rd, R Moncada, A Gonzalez-Roman, C Gimenez and WR Castaneda
Department of Radiology, School of Medicine, Louisiana State University, New Orleans 70112, USA.

OBJECTIVE: This experiment was conducted to evaluate efficacy and safety of the Oasis thrombectomy catheter on arterial thrombosis in dogs. MATERIALS AND METHODS: Thrombosis was induced in 18 femoral arteries of nine mongrel dogs. Recanalization of the thrombosed femoral artery was performed using a thrombectomy catheter 7-10 days after thrombus induction. Pre- and postprocedural arterial status was documented by angiography. After mechanical thrombectomy, the animals were sacrificed and the femoral arteries were harvested and examined macro- and microscopically. Additionally, in vitro fragmentation was carried out to determine particle size and distribution from the recovered effluent. RESULTS: Subacute thrombosis was successfully created in 15 femoral arteries. Full recanalization was achieved in 80% (12/15) of the thrombosed femoral arteries without any residual thrombus. No significant downstream embolization was documented angiographically. Endothelial denudation was observed in all the treated arteries along with occasional disruption of the internal elastic lamina. No medial injury was seen. Ninety-eight percent of thrombus was liquefied, defined as particles smaller than 15 microm, by the catheter. Particles larger than 400 microm represented 0.27% of the original clot weight. CONCLUSION: Occluded femoral arteries with 7- to 10-day-old thrombus can be efficiently recanalized with the Oasis catheter in dogs without any significant complication. This thrombectomy catheter appears to be highly effective and safe and requires no sophisticated equipment. Blood loss was our major concern regarding use of this catheter but can be minimized by strictly controlling activation time and restricting the inflow into the vascular segment being treated.
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W. Hopfner, Z. Qian, and W. R. Castaneda
Recanalization of Thrombosed Femoral Arteries with a Hydraulic Catheter
Am. J. Roentgenol., October 1, 2000; 175(4): 1190 - 1191.
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