HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fernández-Latorre, F. Articles by Arenas-Jiménez, J. Search for Related Content PubMed PubMed Citation Articles by Fernández-Latorre, F. Articles by Arenas-Jiménez, J. Social Bookmarking                      What's this?

Langerhans' Cell Histiocytosis of the Temporal Bone in Pediatric Patients

Imaging and Follow-Up

¹ Department of Radiology, Hospital General Universitario de Alicante, C. Pintor Baeza s.n., Alicante 03010, Spain.
² Department of Pediatric Radiology, Hospital Universitario La Fe, Avda. Campanar, 21, Valencia 46009, Spain.

OBJECTIVE. The purpose of this study was to review the initial clinical and radiologic manifestations and the follow-up of pediatric patients with Langerhans' cell histiocytosis affecting the temporal bone.

MATERIALS AND METHODS. We retrospectively studied 14 patients with Langerhans' cell histiocytosis affecting the temporal bone. All patients were examined initially and sequentially with CT. In six patients, MR imaging was also done.

RESULTS. Temporal bone involvement was the initial form of presentation in 12 patients. In eight patients, temporal bone involvement presented as an isolated manifestation, and in four it was associated with multisystemic involvement. In the remaining two patients, temporal bone involvement appeared during the course of the Langerhans' cell histiocytosis. Bilateral involvement was seen in four patients. In two patients, the temporal bone was affected only at the petrous apex. CT showed destruction of bone in all 14 patients and an associated soft-tissue homogeneous mass after injection of IV contrast material in 12 patients. CT showed a heterogeneous appearance of the soft-tissue mass in two patients. The average period of follow-up was 5 years. In seven of the 14 patients, the disease had a satisfactory evolution in which the bony lesions of the temporal bone reossified and remodeled over the course of a year.

CONCLUSION. In Langerhans' cell histiocytosis, involvement of the temporal bone is usually seen on radiographs as extensive lytic lesions associated with soft-tissue masses. The lesions that remit show early disappearance of the soft-tissue mass, followed by reossification and remodeling of the involved bone. Patients with limited initial involvement of the temporal bone have a better prognosis on long-term follow-up than do patients with the multisystemic form.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				N. D'Ambrosio, S. Soohoo, C. Warshall, A. Johnson, and S. Karimi Craniofacial and Intracranial Manifestations of Langerhans Cell Histiocytosis: Report of Findings in 100 Patients Am. J. Roentgenol., August 1, 2008; 191(2): 589 - 597. [Abstract] [Full Text] [PDF]

				S E J CONNOR, R LEUNG, and S NATAS Imaging of the petrous apex: a pictorial review Br. J. Radiol., May 1, 2008; 81(965): 427 - 435. [Abstract] [Full Text] [PDF]

				S. Schmidt, G. Eich, A. Geoffray, S. Hanquinet, P. Waibel, R. Wolf, I. Letovanec, L. Alamo-Maestre, and F. Gudinchet Extraosseous Langerhans Cell Histiocytosis in Children RadioGraphics, May 1, 2008; 28(3): 707 - 726. [Abstract] [Full Text] [PDF]