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Original Report |
1
Department of Pediatrics, Endocrinology Research Center, Moscow 117036,
Russia.
2
Department of International Health and Radiation Research, Nagasaki University
School of Medicine, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
3
Department of Pediatrics, Nagasaki University School of Medicine, Nagasaki
852-8104, Japan.
4
MRI Department, Endocrinology Research Center, Moscow 117036, Russia.
OBJECTIVE. The aim of this study was to clafify the relationship between morphologic changes of the pituitary gland and the genotype of Prophet of Pit-1 (PROP1), a newly discovered gene responsible for congenital combined pituitary hormone deficiency, in a series of eight humans with this disorder.
CONCLUSION. Congenital hypoplasia of the anterior pituitary gland is the most common MR imaging finding in patients with combined pituitary hormone deficiency. Our findings suggest a crucial role for PROP1 in pituitary organogenesis as well as anterior pituitary cell differentiation.
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