| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1
Department of Radiology, UCSF Medical Center, Box 1667, San Francisco, CA
94143-1667.
2
Present address: Department of Radiology, University of Michigan Health
System, 1500 E. Medical Center Dr., TC 2910F, Ann Arbor, MI 48109-0326.
OBJECTIVE. We determined differences in the rates of recall, biopsy, and cancer detection for screening mammography as a function of adiposity.
MATERIALS AND METHODS. Eighty-eight thousand three hundred forty-six consecutive screening mammography examinations were performed from April 1985 to August 1997. Patient weights were normalized to ideal weight correcting for height and were subdivided into adiposity cohorts including underweight by greater than 10%; ideal weight ± 10%; overweight by 11-24%; overweight by 25-39%; and overweight by greater than 40%. The rates of recall, biopsy, cancer detection, and cancer stage were calculated and were analyzed using the chi-square test for trend. Cancer size was analyzed using linear regression analysis.
RESULTS. Reliable (p < 0.05) and meaningful differences were seen between cohorts of increasing adiposity for rates of recall, biopsy, and cancer detection. An increase in recall rate occurred with progressively increasing adiposity (3.88%, 4.89%, 5.11%, 5.47%, 5.55% [p < 0.0001]). The rate of biopsy also increased with increasing adiposity (0.98%, 1.31%, 1.35%, 1.59%, 1.65% [p < 0.0002]), as did the rate of screening-detected cancer (number of cases of cancer per 1000 women screened) (3.74, 4.29, 5.34, 4.70, 6.04 [p < 0.015]). Finally, increased adiposity also correlated with increased median cancer size (p < 0.02) and with more advanced stage at diagnosis (p = 0.046).
CONCLUSION. Increasing adiposity correlates with progressive increases in the rates of recall, biopsy, and cancer detection for women undergoing screening mammography. Increasing adiposity also correlates with increased cancer size and stage, providing further support for obesity as a risk factor for breast cancer.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Sassi, H. S. Luft, and E. Guadagnoli Reducing Racial/Ethnic Disparities in Female Breast Cancer: Screening Rates and Stage at Diagnosis Am J Public Health, December 1, 2006; 96(12): 2165 - 2172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Porter, K. M. Inglis, L. A. Wood, and P. J. Veugelers Effect of Obesity on Presentation of Breast Cancer Ann. Surg. Oncol., March 1, 2006; 13(3): 327 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Elmore, P. A. Carney, L. A. Abraham, W. E. Barlow, J. R. Egger, J. S. Fosse, G. R. Cutter, R. E. Hendrick, C. J. D'Orsi, P. Paliwal, et al. The Association Between Obesity and Screening Mammography Accuracy Arch Intern Med, May 24, 2004; 164(10): 1140 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Roubidoux, J. S. Kaur, K. A. Griffith, J. Sloan, C. Wilson, P. Novotny, and M. Lobell Correlates of Mammogram Density in Southwestern Native-American Women Cancer Epidemiol. Biomarkers Prev., June 1, 2003; 12(6): 552 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Demark-Wahnefried, B. L. Peterson, E. P. Winer, L. Marks, N. Aziz, P. K. Marcom, K. Blackwell, and B. K. Rimer Changes in Weight, Body Composition, and Factors Influencing Energy Balance Among Premenopausal Breast Cancer Patients Receiving Adjuvant Chemotherapy J. Clin. Oncol., May 1, 2001; 19(9): 2381 - 2389. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
