HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Takayasu, K. Articles by Ohto, M. Search for Related Content PubMed PubMed Citation Articles by Takayasu, K. Articles by Ohto, M. Social Bookmarking                      What's this?

Comparison of CT Findings with Resected Specimens After Chemoembolization with Iodized Oil for Hepatocellular Carcinoma

¹ Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 114-0045, Japan.
² First Department of Surgery, Kyoto University, 54, Kawara-cho, Seigoin, Sakyo-ku, Kyoto 606-8507, Japan.
³ Department of Radiology, Nara Prefectural Medical College, 840, Shijo-cho, Kashihara, Nara 634-8522, Japan.
⁴ First Department of Medicine, Chiba School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba 260-8766, Japan.
⁵ Department of Surgery, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.
⁶ Department of Surgery, Tokyo Women's Medical College, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
⁷ Department of Radiology, Wakayama Prefectural Medical College, 811-1, Kimidera, Wakayama 641-8509, Japan.
⁸ First Department of Surgery, Hyogo School of Medicine, 1-1, Bukogawa-cho, Nishimiya, Hyogo 663-8501, Japan.
⁹ Department of Surgery, Chiba-nishi Hospital, 107-1, Kanegasaku, Matsudo, Chiba 270-2251, Japan.

OBJECTIVE. We assessed the role of dynamic CT in the evaluation of the efficacy of transarterial chemoembolization with iodized oil for hepatocellular carcinoma.

MATERIALS AND METHODS. We examined 41 hepatocellular carcinoma lesions (mean diameter, 5.0 cm) in 40 patients (mean age, 60.6 years) who underwent transarterial injection of iodized oil alone (n = 3) or emulsion of iodized oil and doxorubicin hydrochloride (n = 10) followed by gelatin sponge particles (n = 27) and subsequent hepatectomy. On dynamic CT performed within 3 weeks before oily transarterial chemoembolization and within 4 weeks before surgery, we calculated the rate of necrosis on the basis of the assumption that the portion that retained iodized oil represented necrosis. We also calculated the reduction rate of the tumor. CT findings were compared with pathologic findings of resected specimens.

RESULTS. Pathologic specimens and the necrosis rate measured on CT showed a good correlation (r = 0.83) when the portion of tumor that retained iodized oil was considered necrosis. No correlation existed if the portion that retained iodized oil was considered viable. We noted no significant correlation (r = 0.38) between the reduction rate of the tumor and necrosis rate. Also, we noted no correlation (r = 0.52) between the interval between transarterial oily chemoembolization and surgery and the reduction rate of the tumor.

CONCLUSION. CT is suitable for the evaluation of the efficacy of oily chemoembolization for hepatocellular carcinoma on the basis of the assumption that the portion of tumor that retains iodized oil is necrotic. The rate of tumor size reduction measured on CT did not correlate with the therapeutic effect of chemoembolization.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Liapi, J.-F. Geschwind, J. A. Vossen, M. Buijs, C. S. Georgiades, D. A. Bluemke, and I. R. Kamel Functional MRI Evaluation of Tumor Response in Patients with Neuroendocrine Hepatic Metastasis Treated with Transcatheter Arterial Chemoembolization Am. J. Roentgenol., January 1, 2008; 190(1): 67 - 73. [Abstract] [Full Text] [PDF]

				E. Liapi and J.-F. H. Geschwind Transcatheter and Ablative Therapeutic Approaches for Solid Malignancies J. Clin. Oncol., March 10, 2007; 25(8): 978 - 986. [Abstract] [Full Text] [PDF]

				A. L. Keppke, R. Salem, D. Reddy, J. Huang, J. Jin, A. C. Larson, and F. H. Miller Imaging of Hepatocellular Carcinoma After Treatment with Yttrium-90 Microspheres Am. J. Roentgenol., March 1, 2007; 188(3): 768 - 775. [Abstract] [Full Text] [PDF]

				H. S. Lim, Y. Y. Jeong, H. K. Kang, J. K. Kim, and J. G. Park Imaging Features of Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization and Radiofrequency Ablation Am. J. Roentgenol., October 1, 2006; 187(4): W341 - W349. [Abstract] [Full Text] [PDF]

				H. S. Park, S. H. Lee, Y. I. Kim, J. S. Lee, M. K. Lim, J.-W. Park, J. H. Lee, and C.-M. Kim Postbiopsy Arterioportal Fistula in Patients with Hepatocellular Carcinoma: Clinical Significance in Transarterial Chemoembolization Am. J. Roentgenol., February 1, 2006; 186(2): 556 - 561. [Abstract] [Full Text] [PDF]

				Y. Minami, M. Kudo, T. Kawasaki, M. Kitano, H. Chung, K. Maekawa, and H. Shiozaki Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma: Usefulness of Coded Phase-Inversion Harmonic Sonography Am. J. Roentgenol., March 1, 2003; 180(3): 703 - 708. [Abstract] [Full Text] [PDF]

				K. Numata, K. Tanaka, T. Kiba, S. Matsumoto, S. Iwase, K. Hara, H. Kirikoshi, K. Morita, S. Saito, and H. Sekihara Nonresectable Hepatocellular Carcinoma: Improved Percutaneous Ethanol Injection Therapy Guided by CO2-Enhanced Sonography Am. J. Roentgenol., October 1, 2001; 177(4): 789 - 798. [Abstract] [Full Text] [PDF]