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AJR 2000; 175:821-825
© American Roentgen Ray Society

Quantitative Diffusion Measurements in Focal Multiple Sclerosis Lesions

Correlations with Appearance on TI-Weighted MR Images

Annette O. Nusbaum1, Dongfeng Lu1, Cheuk Y. Tang1 and Scott W. Atlas1,2

1 Department of Radiology, Mount Sinai School of Medicine, One Gustave L. Levy PI., New York, NY 10029.
2 Present address: Department of Radiology, Rm. S-047, Stanford University Medical Center, 300 Pasteur Dr., Stanford, CA.

OBJECTIVE. Relative hypointensity on T1-weighted MR imaging has been suggested as a putative disability marker. The purpose of our study was to determine if there are quantifiable diffusion differences among focal multiple sclerosis lesions that appear differently on conventional T1-weighted MR images. We hypothesized that markedly hypointense lesions on unenhanced T1-weighted images would have significantly increased diffusion compared with other lesions, and enhancing portions of lesions would have different diffusion compared with nonenhancing lesions.

SUBJECTS AND METHODS. Average apparent diffusion coefficient (ADC) was calculated for 107 lesions identified on T2-weighted images in 16 patients with multiple sclerosis and was compared with the ADC of normal white matter in 16 age- and sex-matched control subjects. Seventy-five nonenhancing lesions (29 isointense, 46 hypointense) and 32 enhancing lesions (6 isointense, 26 hypointense) were categorized on the basis of unenhanced T1-weighted MR imaging.

RESULTS. Hypointense and isointense nonenhancing lesions both showed significantly higher ADC than normal white matter (p < 0.0001). Hypointense nonenhancing lesions showed higher ADC values than isointense nonenhancing lesions (p < 0.0001). Diffusion in enhancing portions of enhancing lesions was decreased when compared with nonenhancing portions.

CONCLUSION. Quantitative diffusion data from MR imaging differ among multiple sclerosis lesions that appear different from each other on T1-weighted images. These quantitative diffusion differences imply microstructural differences, which may prove useful in documenting irreversible disease.


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