HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pirovano, G. Articles by Spinazzi, A. Search for Related Content PubMed PubMed Citation Articles by Pirovano, G. Articles by Spinazzi, A. Social Bookmarking                      What's this?

Evaluation of the Accuracy of Gadobenate Dimeglumine-Enhanced MR Imaging in the Detection and Characterization of Focal Liver Lesions

¹ Bracco, Medical and Regulatory Affairs, Via Egidio Folli 50, 20134 Milan, Italy.
² Department of Radiology, Scientific Institute S. Raffaele, University Hospital, Via Olgettina 60, 20132 Milan, Italy.
³ Department of Radiology, Hospital Universitario Dr. Peset, Valencia, Spain.
⁴ Il Servizio di Radiologia, Ente Ospedaliero «Spedali Civili», Piazzale Ospedale 1, 25100 Brescia, Italy.
⁵ Instituto di Radiologia, Policlinico «A. Gemelli», Largo A. Gemelli 8, 00168 Roma, Italy.
⁶ MR Imaging Centre, Princess Grace Hospital, Ave. Pasteur, 98000 Monaco, Principaute de Monaco.
⁷ Ludwig-Maximilians-Universität-München, Institut für Radiologische Klinik, Klinikum Marchioninistr. 15, 81377 München, Germany.
⁸ Westfälische Wilhelms-Universität Münster, Institut für Klinische Radiologie, Röntgendiagnostik, A.-Schweitzer-Str. 33, 48129 Münster, Germany.
⁹ Institut für Röntgendiagnostik, Medizinische Fakultät der Humboldt-Universität, Charité, Schumannstr. 20/21, 10098 Berlin, Germany.

OBJECTIVE. We evaluated the extent to which hepatic lesion characterization and detection is improved by using gadobenate dimeglumine for enhancement of MR images.

MATERIALS AND METHODS. Eighty-six patients were imaged before gadobenate dimeglumine administration, immediately after the 2 mL/sec bolus administration of a 0.05 mmol/kg dose (dynamic imaging), and at 60-120 min after the IV infusion at 10 mL/min of a further 0.05 nmol/kg dose (delayed imaging). The accuracy for lesion characterization was assessed for a total of 107 lesions. Sensitivity for lesion detection was assessed for a total of 149 lesions detected on either intra-operative sonography, iodized oil CT, CT during arterial portography, or follow-up contrast-enhanced CT as the gold standard.

RESULTS. The accuracy in differentiating benign from malignant liver lesions increased from 75% and 82% (the findings of two observers) on unenhanced images alone, to 89% and 80% on dynamic images alone (p < 0.001, p = 0.8), and to 90.7% when combining the unenhanced and dynamic image sets (p < 0.001, p = 0.023). Delayed images did not further improve accuracy (90% and 91%; p = 0.002, p < 0.05). A similar trend was apparent in terms of accuracy for specific diagnosis: values ranged from 49% and 62% on unenhanced images alone, to 76% and 70% on combined unenhanced and dynamic images (p < 0.001, p = 0.06), and to 75% and 70% on inclusion of delayed images (p < 0.001, p = 0.12). The sensitivity for lesion detection increased from 77% and 81% on unenhanced images alone, to 87% and 85% on combined unenhanced and dynamic images (p = 0.001, p = 0.267), and to 92% and 89% when all images were considered (p < 0.001, p = 0.01).

CONCLUSION. Contrast-enhanced dynamic MR imaging with gadobenate dimeglumine significantly increases sensitivity and accuracy over unenhanced imaging for the characterization of focal hepatic lesions, and delayed MR imaging contributes to the improved detection of lesions.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. H. Choi, J. M. Lee, N. C. Yu, K.-S. Suh, J.-J. Jang, S. H. Kim, and B. I. Choi Hepatocellular Carcinoma in Liver Transplantation Candidates: Detection with Gadobenate Dimeglumine-Enhanced MRI Am. J. Roentgenol., August 1, 2008; 191(2): 529 - 536. [Abstract] [Full Text] [PDF]

				E. Leen, P. Ceccotti, C. Kalogeropoulou, W. J. Angerson, S. J. Moug, and P. G. Horgan Prospective multicenter trial evaluating a novel method of characterizing focal liver lesions using contrast-enhanced sonography. Am. J. Roentgenol., June 1, 2006; 186(6): 1551 - 1559. [Abstract] [Full Text] [PDF]

				L. Grazioli, G. Morana, M. A. Kirchin, and G. Schneider Accurate Differentiation of Focal Nodular Hyperplasia from Hepatic Adenoma at Gadobenate Dimeglumine-enhanced MR Imaging: Prospective Study Radiology, July 1, 2005; 236(1): 166 - 177. [Abstract] [Full Text] [PDF]

				T. H. Bryant, M. J. Blomley, T. Albrecht, P. S. Sidhu, E. L. S. Leen, R. Basilico, J. M. Pilcher, L. H. Bushby, C. W. Hoffmann, C. J. Harvey, et al. Improved Characterization of Liver Lesions with Liver-Phase Uptake of Liver-specific Microbubbles: Prospective Multicenter Study Radiology, September 1, 2004; 232(3): 799 - 809. [Abstract] [Full Text] [PDF]

				L. Grazioli, G. Morana, M. P. Federle, G. Brancatelli, M. Testoni, M. A. Kirchin, K. Menni, L. Olivetti, N. Nicoli, and C. Procacci Focal Nodular Hyperplasia: Morphologic and Functional Information from MR Imaging with Gadobenate Dimeglumine Radiology, December 1, 2001; 221(3): 731 - 739. [Abstract] [Full Text] [PDF]