HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lecouvet, F. E. Articles by Maldague, B. Search for Related Content PubMed PubMed Citation Articles by Lecouvet, F. E. Articles by Maldague, B. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Bone Marrow Transplantation in Patients with Multiple Myeloma

Prognostic Significance of MR Imaging

¹ Department of Radiology and Medical Imaging, UCL 10/2942, Saint Luc University Hospital, Université Catholique de Louvain, Hippocrate Ave., 10, B1200 Brussels, Belgium
² Department of Hematology, Saint Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.

OBJECTIVE. This study in myeloma patients treated with myeloablative therapy and bone marrow transplantation assessed the prognostic value of MR imaging before and after treatment of the bone marrow and the prognostic value of an index reflecting changes on MR images obtained before and after treatment.

SUBJECTS AND METHODS. MR images (T1-weighted images before and after injection of gadolinium and T2^*-weighted images) of the spine and pelvis were obtained 1 month before and 1 month after marrow transplantation in 25 consecutive patients with stage III myeloma. Pre- and posttreatment MR imaging patterns of marrow involvement (normal, focal, diffuse), number of focal lesions, and a "marrow evolution index" (0-8 on the basis of comparison of the lesions [number, size, contrast enhancement] and of the surrounding marrow background on pre- and posttreatment MR images) were determined. Hematologic and MR imaging parameters were correlated with the quality of response to treatment (complete versus partial remission) and with relapse-free and overall survival.

RESULTS. Response quality did not differ among categories of patients determined on the basis of MR images. Individual MR imaging parameters did not correlate with response duration and survival. Patients with a low marrow evolution index had significantly longer relapse-free (p < 10^-3) and overall survival (p = 0.005) than patients with a high index.

CONCLUSION. Individual MR imaging parameters before and after treatment had no prognostic significance in our series of myeloma patients treated with marrow transplantation. Comparison of MR images before and after treatment using a marrow evolution index may help predict response duration and survival.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				L. S. Steinbach "MRI in the Detection of Malignant Infiltration of Bone Marrow"--A Commentary Am. J. Roentgenol., June 1, 2007; 188(6): 1443 - 1445. [Full Text] [PDF]

				L. A. Moulopoulos, D. Gika, A. Anagnostopoulos, K. Delasalle, D. Weber, R. Alexanian, and M. A. Dimopoulos Prognostic significance of magnetic resonance imaging of bone marrow in previously untreated patients with multiple myeloma Ann. Onc., November 1, 2005; 16(11): 1824 - 1828. [Abstract] [Full Text] [PDF]

				E. J. C. Angtuaco, A. B. T. Fassas, R. Walker, R. Sethi, and B. Barlogie Multiple Myeloma: Clinical Review and Diagnostic Imaging Radiology, April 1, 2004; 231(1): 11 - 23. [Abstract] [Full Text] [PDF]