AJR Custom publishing of AJR articles and ARRS Cat. Course
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spuentrup, E.
Right arrow Articles by Guenther, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spuentrup, E.
Right arrow Articles by Guenther, R. W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
AJR 2001; 176:351-358
© American Roentgen Ray Society

Diffusion-Weighted MR Imaging for Differentiation of Benign Fracture Edema and Tumor Infiltration of the Vertebral Body

Elmar Spuentrup1,2, Arno Buecker1, Gerhard Adam1, Joop J. van Vaals3 and Rolf W. Guenther1

1 Cardiovascular Division/Cardiac MRI, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215.
2 Present address: Department of Diagnostic Radiology, Technical University of Aachen, Pauwelsstr. 30, 52057 Aachen, Germany.
3 Philips Medical Systems, P.O. 10000, 5680 Best, DA, The Netherlands.

OBJECTIVE. The aim of this study was to investigate diffusion-weighted MR imaging for differentiation of benign fracture edema and tumor infiltration with and without accompanying fracture.

SUBJECTS AND METHODS. In 10 volunteers, diffusion-weighted spin-echo, fat-suppressed spin-echo, and stimulated-echo sequences were optimized on a clinical 1.5-T scanner. In 34 patients, MR imaging with and without diffusion-sensitizing gradients (b = 598 sec/mm2 in spin-echo and fat-suppressed spin-echo, b = 360 sec/mm2 in stimulated-echo) was performed. Thirty-five lesions were analyzed, with 18 caused by acute (<=10 days old) osteoporotic or traumatic fractures and 17 caused by untreated malignant vertebral infiltration including nine fractures. Signal attenuation in diffusion-weighted images and contrast-to-noise ratio were calculated. The diffusion-weighted images were analyzed by two radiologists.

RESULTS. Images from three of 34 patients were excluded because of motion artifact. In osteoporotic and traumatic fractures, a strong signal attenuation of bone marrow edema was seen. In contrast to this, malignant-tumor infiltration caused only minor signal attenuation (p < 0.05), independent of accompanying pathologic fracture. All sequences showed identical changes of signal intensities. In four patients, initial diagnosis was changed by the findings in the diffusion-weighted images.

CONCLUSION. Diffusion-weighted spin-echo, fat-suppressed spin-echo, and stimulated-echo sequences are equally suitable for imaging of the spine. Calculation of signal attenuation and observation of signal characteristics allowed differentiation of benign fracture edema and tumor infiltration and provided excellent distinction between benign and malignant vertebral fractures in our series.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
A. Srinivasan, R. Dvorak, K. Perni, S. Rohrer, and S.K. Mukherji
Differentiation of Benign and Malignant Pathology in the Head and Neck Using 3T Apparent Diffusion Coefficient Values: Early Experience
AJNR Am. J. Neuroradiol., January 1, 2008; 29(1): 40 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
A. Y. Oner, L. Aggunlu, S. Akpek, T. Tali, and A. Celik
Diffusion-Weighted Imaging of the Appendicular Skeleton with a Non Carr-Purcell-Meiboom-Gill Single-Shot Fast Spin-Echo Sequence
Am. J. Roentgenol., December 1, 2007; 189(6): 1494 - 1501.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A.J. Nemeth, J.W. Henson, M.E. Mullins, R.G. Gonzalez, and P.W. Schaefer
Improved Detection of Skull Metastasis with Diffusion-Weighted MR Imaging
AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1088 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D.-M. Koh and D. J. Collins
Diffusion-Weighted MRI in the Body: Applications and Challenges in Oncology
Am. J. Roentgenol., June 1, 2007; 188(6): 1622 - 1635.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A.Y. Oner, T. Tali, F. Celikyay, A. Celik, and P. Le Roux
Diffusion-Weighted Imaging of the Spine with a Non-Carr-Purcell-Meiboom-Gill Single-Shot Fast Spin-Echo Sequence: Initial Experience
AJNR Am. J. Neuroradiol., March 1, 2007; 28(3): 575 - 580.
[Abstract] [Full Text] [PDF]

Home page
 ImagingHome page
J Teh, A Imam, and C Watts
Imaging of back pain
Imaging, December 1, 2005; 17(3): 171 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
G A Clines and T A Guise
Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone
Endocr. Relat. Cancer, September 1, 2005; 12(3): 549 - 583.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T. Hamaoka, J. E. Madewell, D. A. Podoloff, G. N. Hortobagyi, and N. T. Ueno
Bone Imaging in Metastatic Breast Cancer
J. Clin. Oncol., July 15, 2004; 22(14): 2942 - 2953.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. Maeda, H. Sakuma, S. E. Maier, and K. Takeda
Quantitative Assessment of Diffusion Abnormalities in Benign and Malignant Vertebral Compression Fractures by Line Scan Diffusion-Weighted Imaging
Am. J. Roentgenol., November 1, 2003; 181(5): 1203 - 1209.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Castillo
Diffusion-Weighted Imaging of the Spine: Is It Reliable?
AJNR Am. J. Neuroradiol., June 1, 2003; 24(6): 1251 - 1253.
[Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
R. Bammer, A. M. Herneth, S. E. Maier, K. Butts, R. W. Prokesch, H. M. Do, S. W. Atlas, and M. E. Moseley
Line Scan Diffusion Imaging of the Spine
AJNR Am. J. Neuroradiol., January 1, 2003; 24(1): 5 - 12.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. M. Herneth, M. O. Philipp, J. Naude, M. Funovics, R. R. Beichel, R. Bammer, and H. Imhof
Vertebral Metastases: Assessment with Apparent Diffusion Coefficient
Radiology, December 1, 2002; 225(3): 889 - 894.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. Baur, A. Stabler, S. Arbogast, H. R. Duerr, R. Bartl, and M. Reiser
Acute Osteoporotic and Neoplastic Vertebral Compression Fractures: Fluid Sign at MR Imaging
Radiology, December 1, 2002; 225(3): 730 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. D. Eastwood, R. T. Vollmer, and J. M. Provenzale
Diffusion-Weighted Imaging in a Patient with Vertebral and Epidural Abscesses
AJNR Am. J. Neuroradiol., March 1, 2002; 23(3): 496 - 498.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
J H M Chan, W C G Peh, E Y K Tsui, L F Chau, K K Cheung, K B Chan, M K Yuen, E T H Wong, and K P C Wong
Acute vertebral body compression fractures: discrimination between benign and malignant causes using apparent diffusion coefficients
Br. J. Radiol., March 1, 2002; 75(891): 207 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. D. Eastwood, D. A. Turner, R. E. McLendon, and J. M. Provenzale
Diffusion-Weighted MR Imaging in a Patient with Spinal Meningioma
Am. J. Roentgenol., December 1, 2001; 177(6): 1479 - 1481.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Roentgen Ray Society.