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Usefulness of an Artificial Neural Network for Differentiating Benign from Malignant Pulmonary Nodules on High-Resolution CT

Evaluation with Receiver Operating Characteristic Analysis

¹ Department of Radiology, University of Occupational and Environmental Health School of Medicine, Iseigaoka 1-1, Yahatanishi-ku, Kitakyushu-shi, Japan 807-8555.
² Nippon Bunri University General Research Center, Nippon Bunri University, Ichiki 1727, Oita-shi, Japan 870-0397.
³ Kurt Rossmann Laboratories for Radiologic Image Research, Department of Radiology, The University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637.

OBJECTIVE. The purpose of our study was to use an artificial neural network to differentiate benign from malignant pulmonary nodules on high-resolution CT findings and to evaluate the effect of artificial neural network output on the performance of radiologists using receiver operating characteristic analysis.

MATERIALS AND METHODS. We selected 155 cases with pulmonary nodules less than 3 cm (99 malignant nodules and 56 benign nodules). An artificial neural network was used to distinguish benign from malignant nodules on the basis of seven clinical parameters and 16 radiologic findings that were extracted by attending radiologists using subjective rating scales. In the observer test, 12 radiologists (four attending radiologists, four radiology fellows, and four radiology residents) were presented with high-resolution CT images, first without and then with the artificial neural network output. Observer performance was evaluated by means of receiver operating characteristic analysis using a continuous rating scale.

RESULTS. The artificial neural network showed a high performance in differentiating benign from malignant pulmonary nodules (A_z = 0.951). The average A_z value for all radiologists increased by a statistically significant level, from 0.831 to 0.959, with the use of the artificial neural network output.

CONCLUSION. Our computerized scheme using the artificial neural network can improve the diagnostic accuracy of radiologists who are differentiating benign from malignant pulmonary nodules on high-resolution CT.

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