HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marom, E. M. Articles by McAdams, H. P. Search for Related Content PubMed PubMed Citation Articles by Marom, E. M. Articles by McAdams, H. P. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Usefulness of Imaging-Guided Catheter Drainage and Talc Sclerotherapy in Patients with Metastatic Gynecologic Malignancies and Symptomatic Pleural Effusions

¹ Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710.
² Department of Radiology, The University of Texas M. D. Anderson Cancer Center, Box 57, Houston, TX 77030.
³ Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710.

OBJECTIVE. The purpose of our study was to assess the usefulness of imaging-guided catheter drainage and talc sclerotherapy in patients with metastatic gynecologic malignancies and symptomatic pleural effusions and to assess the affect of ascites on the success rate of this treatment.

MATERIALS AND METHODS. Twenty-five patients (mean age, 63 years) with metastatic gynecologic malignancies who had 26 symptomatic effusions treated at our institution over a 4-year period with imaging-guided catheter drainage and talc sclerotherapy were included in this study. Response to treatment was assessed by comparing pre-, immediate post-, and 30-day postsclerotherapy chest radiographs. Response to the treatment was graded as complete (no reaccumulation), partial (accumulation above immediate post- but below presclerotherapy level), or no response (reaccumulation to or above the presclerotherapy level). The presence of ascites on CT (n = 23), sonography (n = 1), direct intraoperative visualization (n = 1), or at physical examination (n = 1) was also noted.

RESULTS. Of the 25 patients, 13 patients with 14 treated malignant effusions survived at least 30 days after sclerotherapy and formed the final study group. The remaining patients either died (n = 11) or were lost to follow-up (n = 1). At 30 days, 12 of the 14 treated effusions showed complete responses and one showed a partial response. The overall response rate was 86%. Abdominal ascites was present at the time of treatment in 11 patients (79%) and did not affect the success rate (p > 0.999).

CONCLUSION. Imaging-guided catheter drainage and talc sclerotherapy are an effective treatment for symptomatic pleural effusions in patients with metastatic gynecologic malignancies. Ascites does not adversely affect the response to pleurodesis.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. E. Heffner and J. S. Klein Recent Advances in the Diagnosis and Management of Malignant Pleural Effusions Mayo Clin. Proc., February 1, 2008; 83(2): 235 - 250. [Abstract] [Full Text] [PDF]

				M. Hatfield and E. M. Marom Fluid Removal Limitations in Thoracentesis Am. J. Roentgenol., February 1, 2003; 180(2): 541 - 541. [Full Text] [PDF]