| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 All authors: Department of Medicine and Department of Hepatology, Gastroenterology and Infectious Diseases, University of Düsseldorf, Moorenstr. 5, D-40225 Düsseldorf, Germany.
OBJECTIVE. We assessed the ability of contrast-enhanced sonography to reveal differences between benign and malignant focal hepatic lesions.
SUBJECTS AND METHODS. We examined 67 patients with focal hepatic lesions in a prospective study. The causes of the lesions were confirmed by histology, CT, MR imaging, or scintigraphy. The liver was screened for focal lesions using sonography. Thereafter, 2 g of Levovist (300 mg/mL; 1 mL/sec) was injected IV as a bolus. After a delay of at least 2.5 min without scanning, the liver was examined via three different scans using pulse-inversion sonography.
RESULTS. For the discrimination of malignant versus benign liver
lesions, contrast-enhanced sonography improved sensitivity from 85% to 100%
and specificity from 30% to 63%, as compared with baseline sonography.
Receiver operating characteristic analysis revealed a significant improvement
in this discrimination (Az = 0.692 ± 0.065 at
baseline sonography, Az = 0.947 ± 0.037 with
contrast-enhanced sonography, p < 0.001). Furthermore, a lower
interobserver variability was found for contrast-enhanced sonography (weighted
= 0.947), as compared with baseline sonography (weighted =
0.469). All lesions that had homogeneous enhancement in the late phase of
Levovist enhancement were benign. In distinction, 90% of lesions without
contrast enhancement in the late phase were malignant. All lesions were
malignant that were isoechoic (invisible) on baseline sonography but visible
because of lack of enhancement after injection.
CONCLUSION. Contrast-enhanced sonography has greater specificity and sensitivity than baseline sonography for the differentiation of benign and malignant liver lesions.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Quaia, A. Palumbo, S. Rossi, F. Degobbis, S. Cernic, G. Tona, and M. Cova Comparison of visual and quantitative analysis for characterization of insonated liver tumors after microbubble contrast injection. Am. J. Roentgenol., June 1, 2006; 186(6): 1560 - 1570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nicolau, R. Vilana, V. Catala, L. Bianchi, R. Gilabert, A. Garcia, and C. Bru Importance of Evaluating All Vascular Phases on Contrast-Enhanced Sonography in the Differentiation of Benign from Malignant Focal Liver Lesions Am. J. Roentgenol., January 1, 2006; 186(1): 158 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takeshima, T. Kumada, H. Toyoda, S. Kiriyama, M. Tanikawa, H. Ichikawa, T. Kawachi, and S. Ogawa Comparison of IV Contrast-Enhanced Sonography and Histopathology of Pancreatic Cancer Am. J. Roentgenol., November 1, 2005; 185(5): 1193 - 1200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C F Dietrich, G Schuessler, J Trojan, C Fellbaum, and A Ignee Differentiation of focal nodular hyperplasia and hepatocellular adenoma by contrast-enhanced ultrasound Br. J. Radiol., August 1, 2005; 78(932): 704 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Maruyama, S Matsutani, H Saisho, Y Mine, N Kamiyama, T Hirata, and M Sasamata Real-time blood-pool images of contrast enhanced ultrasound with Definity in the detection of tumour nodules in the liver Br. J. Radiol., June 1, 2005; 78(930): 512 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Kim, J. M. Lee, J. Y. Lee, J. K. Han, S. K. An, C. J. Han, K. H. Lee, S. S. Hwang, and B. I. Choi Value of Contrast-Enhanced Sonography for the Characterization of Focal Hepatic Lesions in Patients with Diffuse Liver Disease: Receiver Operating Characteristic Analysis Am. J. Roentgenol., April 1, 2005; 184(4): 1077 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Catalano, A. Nunziata, R. Lobianco, and A. Siani Real-Time Harmonic Contrast Material-specific US of Focal Liver Lesions RadioGraphics, March 1, 2005; 25(2): 333 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Celik, H. Ozdemir, C. Yucel, S. Gultekin, S. O. Oktar, and M. Arac Characterization of Hyperechoic Focal Liver Lesions: Quantitative Evaluation With Pulse Inversion Harmonic Imaging in the Late Phase of Levovist J. Ultrasound Med., January 1, 2005; 24(1): 39 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. von Herbay, C. Vogt, R. Willers, and D. Haussinger Real-time Imaging With the Sonographic Contrast Agent SonoVue: Differentiation Between Benign and Malignant Hepatic Lesions J. Ultrasound Med., December 1, 2004; 23(12): 1557 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Giorgio, G. Ferraioli, L. Tarantino, G. de Stefano, V. Scala, F. Scarano, C. Coppola, and L. Del Viscovo Contrast-Enhanced Sonographic Appearance of Hepatocellular Carcinoma in Patients with Cirrhosis: Comparison with Contrast-Enhanced Helical CT Appearance Am. J. Roentgenol., November 1, 2004; 183(5): 1319 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Bryant, M. J. Blomley, T. Albrecht, P. S. Sidhu, E. L. S. Leen, R. Basilico, J. M. Pilcher, L. H. Bushby, C. W. Hoffmann, C. J. Harvey, et al. Improved Characterization of Liver Lesions with Liver-Phase Uptake of Liver-specific Microbubbles: Prospective Multicenter Study Radiology, September 1, 2004; 232(3): 799 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Migaleddu, G. Virgilio, D. Turilli, M. Conti, G. Campisi, N. Canu, D. Sirigu, and I. Vincentelli Characterization of Focal Liver Lesions in Real Time Using Harmonic Imaging with High Mechanical Index and Contrast Agent Levovist Am. J. Roentgenol., June 1, 2004; 182(6): 1505 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C F Dietrich, A Ignee, J Trojan, C Fellbaum, and G Schuessler Improved characterisation of histologically proven liver tumours by contrast enhanced ultrasonography during the portal venous and specific late phase of SHU 508A Gut, March 1, 2004; 53(3): 401 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Emoto, R. Fujimitsu, H. Iwasaki, and T. Kawarabayashi Diagnostic Challenges in Patients With Tumors: CASE 3. NORMAL-SIZED OVARIAN CANCER DETECTED BY COLOR DOPPLER ULTRASOUND USING A MICROBUBBLE CONTRAST AGENT J. Clin. Oncol., October 1, 2003; 21(19): 3703 - 3705. [Full Text] [PDF]
|
|
|
|
|
|
A. von Herbay, C. Vogt, and D. Haussinger Pulse Inversion Sonography in the Early Phase of the Sonographic Contrast Agent Levovist: Differentiation Between Benign and Malignant Focal Liver Lesions J. Ultrasound Med., November 1, 2002; 21(11): 1191 - 1200. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
