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AJR 2003; 180:121-128
© American Roentgen Ray Society

MR Imaging of Hepatic Metastases Caused by Neuroendocrine Tumors: Comparing Four Techniques

Clarisse Dromain1, Thierry de Baere1, Eric Baudin2, Joel Galline1, Michel Ducreux3, Valérie Boige3, Pierre Duvillard4, Agnès Laplanche5, Hubert Caillet1, Philippe Lasser6, Martin Schlumberger2 and Robert Sigal1

1 Department of Imaging, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France.
2 Department of Nuclear Medicine, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
3 Department of Medicine, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
4 Department of Pathology, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
5 Department of Statistics, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.
6 Department of Surgery, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.

OBJECTIVE. The aim of our prospective study was to assess the MR imaging characteristics of hepatic metastases of neuroendocrine tumors and to determine the optimal MR sequence for their detection.

SUBJECTS AND METHODS. Thirty-seven consecutive patients with liver metastases from neuroendocrine tumors underwent 1.5-T MR imaging of the liver comprising T2-weighted fast spin-echo with respiratory monitoring, breath-hold T2-weighted single-shot fast spin-echo, and T1-weighted gradient-recalled echo sequences before and after the injection of gadoterate dimeglumine. Images were reviewed independently by three observers for the number, location, and pattern of signal and enhancement of metastases.

RESULTS. A total of 359 metastases were detected, 279 on T2-weighed fast spin-echo, 231 on T2-weighed single-shot fast spin-echo, 272 on unenhanced T1-weighted, 322 on hepatic arterial phase, and 228 on portal venous phase images. Hepatic arterial phase images revealed the greatest number of metastases in 70% of patients, including 35 metastases seen only on this sequence, and was significantly superior to the unenhanced T1-weighted and portal venous phase sequences (p < 0.01). The lesion-to-liver contrast was significantly greatest with T2-weighed fast spin-echo sequences. The enhancement patterns of metastases were predominantly hypervascular, hypovascular, peripheral with progressive fill-in, and delayed in, respectively, 27, four, four, and two patients. Most metastases with peripheral enhancement and progressive fill-in were heterogeneous on T2-weighted images and were without globular peripheral enhancement.

CONCLUSION. Hepatic metastases of neuroendocrine tumors had a typical hypervascular pattern in 73% of patients. Hepatic arterial phase and fast spin-echo T2-weighed sequences are the most sensitive.


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