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1 Department of Radiology, Changi General Hospital, 2, Simei St. 3, S, 529889
Singapore.
2 Department of Nuclear Medicine, Singapore General Hospital, Outram Rd.,
S169610, Singapore.
3 Biostatistics Unit, Division of Clinical Trials and Epidemiological Sciences,
National Cancer Centre Singapore, 11, Hospital Dr., 169610, Singapore.
4 Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jln Tan Tock
Seng, S308433, Singapore.
OBJECTIVE. Our aim was to evaluate the feasibility of acquiring an MR signal intensity–time renographic curve and dynamic serial images in a way similar to that of acquiring radionuclide renograms, with a dynamic gradient-echo sequence and a low-dose gadopentetate dimeglumine technique, using a commonly available 1.5-T MR scanner.
SUBJECTS AND METHODS. Patients who underwent both radionuclide and MR renographic studies within a 3-month period were included in the analysis. This yielded 21 studies from 19 patients. Nineteen of the 21 studies were available for analysis. Two studies were excluded because of technical errors during MR renographic acquisition. Serial MR renograms were obtained using a dynamic two-dimensional spoiled gradient-echo fast low-angle shot T1-weighted sequence. Low-dose IV furosemide and gadopentetate dimeglumine (0.025 mmol/kg of body weight) were administered. Intensity–time curves were obtained from the manually selected regions of interest over the renal parenchyma and whole kidney for calculation of split renal function and assessment of urinary excretion, respectively. Results were compared with those obtained with radionuclide renography.
RESULTS. Good correlation (Pearson's correlation coefficient,
r = 0.97, p < 0.001) was observed when the
volume-corrected split renal function acquired with MR renography was compared
with that obtained with radionuclide renography. There was also good agreement
in the excretory curve patterns (weighted 
observer 1 = 0.77
and observer 2 = 0.81) between the two techniques.
CONCLUSION. Dynamic MR gradient-echo imaging with a low-dose gadopentetate dimeglumine technique can produce an intensity–time curve and serial dynamic images of the urinary system, in a way similar to that of radionuclide renography. This technique allows assessment of split renal function and urinary excretory status and is a feasible alternative to radionuclide renography.
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