HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tateishi, U. Articles by Moriyama, N. Search for Related Content PubMed PubMed Citation Articles by Tateishi, U. Articles by Moriyama, N. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

CT and MRI Features of Recurrent Tumors and Second Primary Neoplasms in Pediatric Patients with Retinoblastoma

¹ Division of Diagnostic Radiology, National Cancer Center Hospital and Research Institute, 5-1-1, Tsukiji, Chuo-Ku, 104-0045 Tokyo, Japan.
² Division of Pathology, National Cancer Center Hospital and Research Institute, Chuo-Ku, 104-0045 Tokyo, Japan.
³ Division of Radiation Oncology, National Cancer Center Hospital and Research Institute, Chuo-Ku, 104-0045 Tokyo, Japan.

OBJECTIVE. The aim of our study was to describe the CT and MRI findings of recurrent tumors and second primary (malignant and benign) neoplasms in patients with retinoblastoma and to evaluate imaging features to assist in distinguishing them.

MATERIALS AND METHODS. Records of 445 pathologically confirmed retinoblastomas were retrospectively reviewed. Thirty-four patients with recurrent retinoblastomas and 15 patients with second primary neoplasms who underwent CT and MRI were evaluated by two radiologists with agreement by consensus.

RESULTS. Invasive patterns of recurrent tumors included type A, intraocular tumor (n = 13); type B, intraorbital tumor with spread into the optic nerve shown as enlargement and marked enhancement of the optic nerve on contrast-enhanced CT or MRI (n = 6); and type C, tumor extending to the lateral aspect of the orbit and invading the brain via the sphenoidal bone (n = 2). Thirty-eight percent of patients with recurrent tumors had distant metastases (n = 7) or leptomeningeal metastases (n = 6). Leptomeningeal metastases were found only in recurrent tumors. Second primary neoplasms included osteosarcoma (n = 5), rhabdomyosarcoma (n = 5), meningioma (n = 4), and other tumors (n = 3). A significant difference was seen between the patients' ages at the time of diagnosis of recurrent tumors and second primary neoplasms (p < 0.0001). Extraorbital tumors were found more frequently among second primary neoplasms than among recurrent tumors (p < 0.001).

CONCLUSION. Both recurrent tumors and second primary neoplasms in patients with retinoblastoma often show characteristic imaging features. The tumor distribution on CT and MRI may help in differentiating recurrent tumors and second primary neoplasms.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. M. Sabourin, A. Jayashankar, and M. E. Mullins Imaging of Osteosarcoma After Irradiation: Self-Assessment Module Am. J. Roentgenol., September 1, 2008; 191(3_Supplement): S28 - S30. [Abstract] [Full Text] [PDF]

				S. M. Sabourin, A. Jayashankar, and M. E. Mullins AJR Teaching File: Lump on the Head Am. J. Roentgenol., September 1, 2008; 191(3_Supplement): S31 - S33. [Full Text] [PDF]

				E. M. Chung, M. D. Murphey, C. S. Specht, R. Cube, and J. Smirniotopoulos From the Archives of the AFIP Pediatric Orbit Tumors and Tumorlike Lesions: Osseous Lesions of the Orbit1 RadioGraphics, July 1, 2008; 28(4): 1193 - 1214. [Abstract] [Full Text] [PDF]