HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Matsuo, M. Articles by Nakamura, H. Search for Related Content PubMed PubMed Citation Articles by Matsuo, M. Articles by Nakamura, H. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Detection of Malignant Hepatic Tumors with Ferumoxides-Enhanced MRI: Comparison of Five Gradient-Recalled Echo Sequences with Different TEs

¹ Department of Radiology, Gifu University School of Medicine, 40 Tsukasamachi, Gifu 500-8705, Japan.
² Department of Nuclear Medicine, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan.
³ Department of Radiology, Osaka University School of Medicine, Osaka 565-0871, Japan.
⁴ Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo 104-0045, Japan.

OBJECTIVE. The purpose of our study was to compare the detectability of malignant hepatic tumors on ferumoxides-enhanced MRI using five gradient-recalled echo sequences at different TEs.

MATERIALS AND METHODS. Ferumoxides-enhanced MRIs obtained in 31 patients with 50 malignant hepatic tumors (33 hepatocellular carcinomas, 17 metastases) were reviewed retrospectively by three independent offsite radiologists. T1-weighted gradient-recalled echo images with TEs of 1.4 and 4.2 msec; T2*-weighted gradient-recalled echo images with TEs of 6, 8, and 10 msec; and T2-weighted fast spin-echo images of livers were randomly reviewed on a segment-by-segment basis. Observer performance was tested using the McNemar test and receiver operating characteristic analysis for the clustered data. Lesion-to-liver contrast-to-noise ratio was also assessed.

RESULTS. Mean lesion-to-liver contrast-to-noise ratios were negative and lower with gradient-recalled echo at 1.4 msec than with the other sequences. Sensitivity was higher (p < 0.05) with gradient-recalled echo at 6, 8, and 10 msec and fast spin-echo sequences (75–83%) than with gradient-recalled echo sequences at 1.4 and 4.2 msec (46–48%), and was higher (p < 0.05) with gradient-recalled echo sequence at 8 msec (83%) than with gradient-recalled echo at 6 msec and fast spin-echo sequences (75–78%). Specificity was comparably high with all sequences (95–98%). The area under the receiver operating characteristic curve (A_z) was greater (p < 0.05) with gradient-recalled echo at 6, 8, and 10 msec and fast spin-echo sequences (A_z = 0.91–0.93) than with gradient-recalled echo sequences at 1.4 and 4.2 msec (A_z = 0.82–0.85).

CONCLUSION. In the detection of malignant hepatic tumors, gradient-recalled echo sequences at 8 msec showed the highest sensitivity and had an A_z value and lesion-to-liver contrast-to-noise ratio comparable with values from gradient-recalled echo sequences at 6 and 10 msec and fast spin-echo sequences.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. F. Hanna, N. Kased, S. W. Kwan, A. C. Gamst, A. C. Santosa, T. Hassanein, and C. B. Sirlin Double-Contrast MRI for Accurate Staging of Hepatocellular Carcinoma in Patients with Cirrhosis Am. J. Roentgenol., January 1, 2008; 190(1): 47 - 57. [Abstract] [Full Text] [PDF]

				M.-J. Kim, J. H. Kim, J. Y. Choi, S. H. Park, J.-J. Chung, K. W. Kim, and D. G. Mitchell Optimal TE for SPIO-enhanced gradient-recalled echo MRI for the detection of focal hepatic lesions. Am. J. Roentgenol., September 1, 2006; 187(3): W255 - W266. [Abstract] [Full Text] [PDF]