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Computer-Assisted Quantitative Analysis of Bone Marrow Edema of the Knee: Initial Experience with a New Method

¹ Department of Radiology, Surgical Radiology Section and Osteoradiology Section, University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria.
² Department of Orthopaedics, LKH Stolzalpe, Stolzalpe, Austria.
³ First Orthopaedic Department, Orthopaedic Hospital Vienna-Speising, Vienna, Austria.
⁴ Corporate Clinical Operations – Biometrics Europe, Schering AG, Berlin, Germany.
⁵ Institute of CT and MRI Diagnostics, Schillerpark, Linz, Austria.

OBJECTIVE. The purpose of this study was to describe a largely observer-independent computer-assisted method for accurate quantitative analysis of bone marrow edema.

MATERIALS AND METHODS. Ten patients with bone marrow edema of the knee were included in the study. Coronal STIR images of the affected knees were obtained using a 1.0-T MR scanner. Size and signal intensity of the bone marrow edema were assessed on the basis of gray-scale value analysis and calculation of a threshold value for differentiating normal and edematous bone marrow. All measurements were carried out three times for statistical analysis.

RESULTS. The intraobserver coefficient of variation was 0.89% for the volume and 0.94% for the signal intensity of the bone marrow edema, showing the small impact of manual interference on results produced with this method.

CONCLUSION. A computer-assisted method for quantification of bone marrow edema has been described. Intraobserver variation was very low, indicating excellent reproducibility of results. Although the method is too time-consuming for clinical use, it is recommended for research purposes.

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