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Giant Cell Interstitial Pneumonia: High-Resolution CT and Pathologic Findings in Four Adult Patients

¹ Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710, Korea.
² Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
³ Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
⁴ Department of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon, Kyungki-Do 420-853, Korea.

OBJECTIVE. The purpose of our study was to describe the high-resolution CT and pathologic findings of giant cell interstitial pneumonia (GIP) in four adult patients.

CONCLUSION. GIP appears on high-resolution CT as ground-glass and irregular linear opacities in both lungs. These CT findings correspond histopathologically to areas of interstitial thickening caused by fibrosis and inflammatory cell infiltration and to areas of intraalveolar accumulation of macrophages and multinucleated giant cells.

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