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1 Department of Clinical Radiology, Hiroshima University Hospital, 1-2-3,
Kasumi-cho, Minami-ku, Hiroshima 734-8551, Japan.
2 Department of Molecular and Internal Medicine, Division of Clinical Medical
Science, Programs for Applied Biomedicine, Graduate School of Biomedical
Sciences, Hiroshima University, Hiroshima, Japan.
3 Department of Radiology, Division of Medical Intelligence and Informatics,
Programs for Applied Biomedicine, Graduate School of Biomedical Sciences,
Hiroshima Univerisity, Hiroshima, Japan.
OBJECTIVE. High reproducibility on coronary calcium scoring is an important factor in monitoring the progression of coronary atherosclerosis. The purposes of this study were, using a 16-MDCT scanner with retrospective reconstruction, to compare the effects of thin-slice images and overlapping image reconstruction on the reproducibility of coronary calcium scoring and to compare 16-MDCT with electron beam CT (EBCT).
MATERIALS AND METHODS. Fifty patients underwent two sequential examinations using both EBCT and MDCT. For MDCT, images were reconstructed from the same raw data using the following thicknesses and increments (thickness/increment): 1.25 mm/1.25 mm, 2.5 mm/2.5 mm, and 2.5 mm/1.25 mm. The Agatston, volume, and mass scores were calculated on four pairs of image sets. Statistical analysis was performed to determine significant differences in interscan variability among image acquisition protocols and among measurement algorithms.
RESULTS. Overlapping reconstructed images (thickness/increment, 2.5 mm/1.25 mm) obtained on a 16-MDCT scanner showed the lowest variability (mean, 13%; median, 10%) when compared with the Agatston score.
CONCLUSION. The use of 16-MDCT with overlapping reconstruction by retrospective reconstruction, yielding low variability of coronary artery calcium measurement on two sequential scans, has an advantage over EBCT in monitoring the progression of atherosclerosis.
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