HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Goh, V. Articles by Bartram, C. I. Search for Related Content PubMed PubMed Citation Articles by Goh, V. Articles by Bartram, C. I. Social Bookmarking                      What's this?

Quantitative Assessment of Colorectal Cancer Perfusion Using MDCT: Inter- and Intraobserver Agreement

¹ Intestinal Imaging Centre, St. Mark's Hospital, Watford Rd., Level 4V, Harrow, Middlesex, HA1 3UJ, United Kingdom.
² Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, United Kingdom.

OBJECTIVE. The objective of our study was to determine inter- and intraobserver agreement of MDCT colorectal cancer perfusion measurements.

SUBJECTS AND METHODS. Thirty-one patients (17 men, 14 women; median age, 69 years) with proven colorectal cancer were examined prospectively using MDCT. A 65-sec dynamic study (cine mode, 4 x 5 mm collimation) was acquired through the tumor after IV contrast administration (100 mL of iopamidol 350, 5 mL/sec). Tumor blood volume, blood flow, mean transit time, and permeability measurements were determined by two independent observers using commercial software. Inter- and intraobserver agreement was assessed using the Bland-Altman test.

RESULTS. The mean difference for interobserver agreement (95% limits of agreement) was -0.81 mL/100 g tissue (-3.14 to 1.52); -9.94 mL/100 g tissue/min (-51.43 to 32.65); -1.09 sec (-7.05 to 4.86); and -2.90 mL/100 g tissue/min (-11.48 to 5.68) for blood volume, blood flow, mean transit time, and permeability, respectively. The intraclass correlation coefficient was 0.83, 0.89, 0.89, and 0.80, respectively. The mean difference for intraobserver agreement (95% limits of agreement) was 0.12 mL/100 g tissue (-1.90 to 2.14); 0.02 mL/100 g tissue/min (-13.13 to 13.17); -0.19 sec (-3.19 to 2.81); and 0.00 mL/100 g tissue/min (-2.45 to 2.45) for observer 1 and 0.26 mL/100 g tissue (-1.46 to 1.98); 4.47 mL/100 g tissue/min (-26.65 to 35.59); -0.21 sec (-2.48 to 2.06); 1.08 mL/100 g tissue/min (-4.92 to 7.08) for observer 2. The intraclass correlation coefficient was 0.86, 0.98, 0.97, 0.98 for observer 1 and 0.93, 0.96, 0.99, and 0.94, respectively, for observer 2.

CONCLUSION. There is greater inter- than intraobserver agreement for CT vascular perfusion measurements of primary colorectal cancer, which must be addressed for reliable clinical application in therapeutic monitoring.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				V. Goh, S. Halligan, A. Gharpuray, D. Wellsted, J. Sundin, and C. I. Bartram Quantitative Assessment of Colorectal Cancer Tumor Vascular Parameters by Using Perfusion CT: Influence of Tumor Region of Interest Radiology, June 1, 2008; 247(3): 726 - 732. [Abstract] [Full Text] [PDF]

				S. C. Faria, C. S. Ng, K. R. Hess, S. Phongkitkarun, J. Szejnfeld, D. Daliani, and C. Charnsangavej CT Quantification of Effects of Thalidomide in Patients with Metastatic Renal Cell Carcinoma Am. J. Roentgenol., August 1, 2007; 189(2): 378 - 385. [Abstract] [Full Text] [PDF]

				A. Hakime, H. Peddi, A. U. Hines-Peralta, C. J. Wilcox, J. Kruskal, S. Lin, T. de Baere, V. D. Raptopoulos, and S. N. Goldberg CT Perfusion for Determination of Pharmacologically Mediated Blood Flow Changes in an Animal Tumor Model Radiology, June 1, 2007; 243(3): 712 - 719. [Abstract] [Full Text] [PDF]

				V. Goh, S. Halligan, and C. I. Bartram Quantitative Tumor Perfusion Assessment with Multidetector CT: Are Measurements from Two Commercial Software Packages Interchangeable? Radiology, March 1, 2007; 242(3): 777 - 782. [Abstract] [Full Text] [PDF]

				V. Goh, S. Halligan, S. A. Taylor, D. Burling, P. Bassett, and C. I. Bartram Differentiation between Diverticulitis and Colorectal Cancer: Quantitative CT Perfusion Measurements versus Morphologic Criteria--Initial Experience Radiology, February 1, 2007; 242(2): 456 - 462. [Abstract] [Full Text] [PDF]

				V Goh, S Halligan, L Gartner, P Bassett, and C I Bartram Quantitative colorectal cancer perfusion measurement by multidetector-row CT: does greater tumour coverage improve measurement reproducibility? Br. J. Radiol., July 1, 2006; 79(943): 578 - 583. [Abstract] [Full Text] [PDF]

				V. Goh, S. Halligan, J.-A. Hugill, and C. I. Bartram Quantitative assessment of tissue perfusion using MDCT: comparison of colorectal cancer and skeletal muscle measurement reproducibility. Am. J. Roentgenol., July 1, 2006; 187(1): 164 - 169. [Abstract] [Full Text] [PDF]

				Q.-S. Ng, V. Goh, H. Fichte, E. Klotz, P. Fernie, M. I. Saunders, P. J. Hoskin, and A. R. Padhani Lung Cancer Perfusion at Multi-Detector Row CT: Reproducibility of Whole Tumor Quantitative Measurements Radiology, May 1, 2006; 239(2): 547 - 553. [Abstract] [Full Text] [PDF]

				D. Sahani, S. Kalva, and P. F. Hahn Response Radiology, February 1, 2006; 238(2): 757 - 757. [Full Text] [PDF]