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The Role of Blood-Brain Barrier Permeability in Brain Tumor Imaging and Therapeutics

¹ Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710.
² Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710.

OBJECTIVE. Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes.

CONCLUSION. Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.

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