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DOI:10.2214/AJR.04.1337
AJR 2005; 185:1045-1047
© American Roentgen Ray Society

Technical Innovation

Contrast-Enhanced Dark Lumen PET/CT and MR Colonography in a Rodent Polyp Model: Initial Results with Histopathologic Correlation

Christiane A. Kuehle1, Patrick Veit1, Gerald Antoch1, Florian Grabellus2, Philippe Robert3, Thomas Beyer1 and Christoph U. Herborn1

1 Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany.
2 Institute of Pathology, University Hospital Essen, Essen, Germany.
3 Guerbet Group, Aulnay-sous-Bois, France.

OBJECTIVE. The objective of this study was to assess the feasibility of PET/CT for the detection of colorectal masses in a rodent polyp model in an intraindividual comparison with dark-lumen MR colonography.

CONCLUSION. Detection of small tumors with PET/CT and MR colonography is possible in a rodent model. The technique thus warrants further evaluation in animal studies as well as in patients with suspected colorectal disease.


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