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Sonographically Depicted Breast Clustered Microcysts: Is Follow-Up Appropriate?

¹ Johns Hopkins Greenspring, 10755 Falls Rd., Suite 440, Lutherville, MD 21093.

OBJECTIVE. The objective of this study was to evaluate outcomes of lesions prospectively classified on breast sonography as clustered microcysts without a discrete solid component.

SUBJECTS AND METHODS. Over a 4-year interval during which 1,900 consecutive breast sonography examinations were obtained at the University of Maryland, 110 examinations (5.8%) yielded 123 lesions so classified. Sonography was performed by a physician using a linear-array broadband transducer (L7.5–12 or L7–13 MHz). Follow-up of at least 24 months was available for 66 lesions, and 14-gauge core biopsy was performed on another 13 lesions. The median patient age was 48 years (range, 32–71 years), and the median lesion size was 8 mm (range, 5–30 mm).

RESULTS. Of the 79 lesions with acceptable follow-up, all were depicted sonographically, 57 (72%) were seen mammographically, and four (5%) were palpable. Of the 13 lesions biopsied, five (38%) showed apocrine metaplasia; five (38%), fibrocystic changes; two (15%), cysts; and one (8%), a microscopic fibroadenoma and cysts. Of the 66 lesions with 2-year follow-up, 35 (53%) were stable, 15 (23%) had resolved, 12 (18%) decreased, and four (6%) minimally increased at 1 year and were then stable (n = 2) or decreased (n = 2) after 2 subsequent years. Fusion of several small cystic spaces was seen in one (2%) of the lesions followed.

CONCLUSION. Breast clustered microcysts are relatively common, seen in 5.8% of breast sonograms. In our series of 79 lesions with follow-up, none proved malignant: Follow-up on an annual basis appears reasonable for most such lesions. Validation of this approach across multiple centers is needed.

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