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Is True FISP Imaging Reliable in the Evaluation of Venous Thrombosis?

¹ Department of Radiology, Harvard Medical School and Beth Israel Deaconess Medical Center, One Deaconess Rd., Boston, MA 02215.
² Department of Radiology, Hospital de Basurto, Bilbao 48013, Spain.
³ Averion Inc., 4 California Ave., Framingham, MA 01701.

OBJECTIVE. The objective of our study was to evaluate the accuracy of true fast imaging with steady-state precession (FISP) in the diagnosis of venous thrombosis using gadolinium-enhanced 3D T1-weighted gradient-echo images and correlative imaging as the gold standard.

MATERIALS AND METHODS. Twenty-five MR examinations were retrospectively reviewed independently by two radiologists to rule out thrombosis in the central veins of the body. The presence of venous thrombus was assessed separately in 80 veins using true FISP and gadolinium-enhanced T1-weighted images. Diagnosis was confirmed by another imaging technique (sonography, CT, and/or conventional venography) in all positive cases. Negative examinations were confirmed using imaging, clinical follow-up, or both.

RESULTS. Venous thrombosis was present in 25 veins in 18 patients. True FISP images had a lower sensitivity (66%) and specificity (70.9%) for the diagnosis of venous thrombosis than gadolinium-enhanced MR images (p < 0.01).

CONCLUSION. True FISP images have lower sensitivity and specificity in the diagnosis of venous thrombosis than gadolinium-enhanced T1-weighted gradient-echo images. True FISP images should not be used exclusively for the diagnosis of venous thrombosis.

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