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Focal Parenchymal Lung Lesions Showing a Potential of False-Positive and False-Negative Interpretations on Integrated PET/CT

¹ Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-dong, Kangnam-gu, Seoul 135-710, Korea.
² Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

OBJECTIVE. We describe a number of benign focal lung lesions with increased ¹⁸F-FDG uptake that simulate lung cancer and malignant lesions that lead to false-negatives due to little ¹⁸F-FDG uptake on integrated PET/CT images.

CONCLUSION. The integration of clinical history, morphologic findings of lung parenchymal lesions on the CT component, and metabolic activities on the PET component of integrated PET/CT can help reduce false interpretation of the study. A lung biopsy may be needed for lesions showing increased ¹⁸F-FDG uptake on PET for tissue confirmation irrespective of their morphology on CT.

Keywords: ¹⁸F-FDG uptake • lung • lung cancer • lung diseases • PET/CT

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