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CT and MRI of Hepatic Abscess in Patients with Chronic Granulomatous Disease

¹ Molecular Imaging Program, National Cancer Institute, Bldg. 10, Rm. B3B69, 9000 Rockville Pike, Bethesda, MD 20892.
² Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
³ Laboratory of Pathology, National Cancer Institute, Bethesda, MD.
⁴ Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, MD.
⁵ Laboratory of Clinical Infectious Diseases, Bethesda, MD.

Abstract

OBJECTIVE. We describe the spectrum of radiologic appearances of hepatic abscesses in patients with chronic granulomatous disease (CGD), a hereditary immunodeficiency presenting in childhood that occurs at a rate of 1 in 200,000-250,000 live births and predisposes patients to infection with catalase-positive organisms.

CONCLUSION. Hepatic abscesses in patients with CGD show an atypical radiologic appearance compared with sporadic hepatic abscesses, and they are characterized by homogeneous enhancement and multiseptal enhancement. In the appropriate clinical setting, the appearance of an enhancing mass should suggest the possibility of a CGD-related hepatic abscess.

Keywords: CT • genetics • infectious diseases • liver disease • MRI

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