HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ng, Q. S. Articles by Padhani, A. R. Search for Related Content PubMed PubMed Citation Articles by Ng, Q. S. Articles by Padhani, A. R. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Quantitative Assessment of Lung Cancer Perfusion Using MDCT: Does Measurement Reproducibility Improve with Greater Tumor Volume Coverage?

¹ Marie Curie Research Wing, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom.
² Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Rd., Northwood, Middlesex, United Kingdom HA6 2RN.
³ Siemens Medical Solutions, Forchheim, Germany.

OBJECTIVE. To date, quantitative assessment of tumor vascularity using perfusion CT has been limited to a single tumor level, with the potential for measurement error in heterogeneous tumors. We aimed to determine if greater z-axis tumor coverage improves the reproducibility of perfusion CT measurements in lung cancer.

SUBJECTS AND METHODS. Paired perfusion studies were performed on 10 patients who had histologically confirmed advanced non-small cell lung cancer. Using 16-MDCT, multiple sequential volumetric acquisitions encompassing the entire tumor were acquired after infusion of IV contrast material. Using Patlak analysis, median values of tumor permeability (mL/100 mL/min) and blood volume (mL/100 mL) were measured for 10-mm z-axis coverage, and for 40-mm z-axis coverage in each of the paired perfusion studies. Measurement reproducibility was evaluated using Bland-Altman statistics.

RESULTS. Mean difference (95% limits of agreement) for tumor permeability was 1.4 (-4.0 to 6.8) for 10-mm coverage and 0.8 (-3.6 to 5.2) for 40-mm coverage. Mean difference (95% limits of agreement) for blood volume was 1.9 (-5.1 to 8.9) for 10-mm coverage and 1.4 (-3.7 to 6.6) for 40-mm coverage. The coefficient of variation for permeability was 18.7% for 10-mm coverage, improving to 11.9% for 40-mm coverage. The coefficient of variation for blood volume was 41.7% for 10-mm coverage, improving to 32.6% for 40-mm coverage.

CONCLUSION. Our results show that an improvement in tumor perfusion measurement reproducibility may be achieved with greater z-axis coverage.

Keywords: lung • lung diseases • MDCT • neoplasms • oncologic imaging • perfusion CT

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				G. Petralia, L. Preda, S. Raimondi, G. D'Andrea, P. Summers, G. Giugliano, F. Chiesa, and M. Bellomi Intra- and Interobserver Agreement and Impact of Arterial Input Selection in Perfusion CT Measurements Performed in Squamous Cell Carcinoma of the Upper Aerodigestive Tract AJNR Am. J. Neuroradiol., June 1, 2009; 30(6): 1107 - 1115. [Abstract] [Full Text] [PDF]

				A. Tognolini, R. Schor-Bardach, O. S. Pianykh, C. J. Wilcox, V. Raptopoulos, and S. N. Goldberg Body Tumor CT Perfusion Protocols: Optimization of Acquisition Scan Parameters in a Rat Tumor Model Radiology, June 1, 2009; 251(3): 712 - 720. [Abstract] [Full Text] [PDF]

				V. Goh, J. Liaw, C. I. Bartram, and S. Halligan Effect of Temporal Interval Between Scan Acquisitions on Quantitative Vascular Parameters in Colorectal Cancer: Implications for Helical Volumetric Perfusion CT Techniques Am. J. Roentgenol., December 1, 2008; 191(6): W288 - W292. [Abstract] [Full Text] [PDF]