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DOI:10.2214/AJR.04.1592
AJR 2006; 187:W636-W643
© American Roentgen Ray Society

Clinical Observations

Cytomegalovirus Pneumonia After Stem Cell Transplantation: Correlation of CT Findings with Clinical Outcome in 30 Patients

Marius S. Horger1, Christina Pfannenberg1, Hermann Einsele2, Robert Beck3, Holger Hebart2, Claudia Lengerke2, Reinhard Vonthein4, Manfred Wehrmann5, Christoph Faul2 and Claus Claussen1

1 Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Strasse 3, Tuebingen 72076, Germany.
2 Department of Hematology-Oncology, Eberhard-Karls-University, Tuebingen, Germany.
3 Institute of Medical Virology, Eberhard-Karls-University, Tuebingen, Germany.
4 Department of Medical Biometry, Eberhard-Karls-University, Tuebingen, Germany.
5 Department of Pathology, Eberhard-Karls-University, Tuebingen, Germany.

OBJECTIVE. The purpose of our study was to assess the correlation between early high-resolution CT findings of cytomegalovirus (CMV) pneumonia in patients with blood disorders and their clinical outcomes.

CONCLUSION. The initial high-resolution CT findings in immunocompromised patients with CMV pneumonia seem to predict the patient's outcome being unfavorable in those forms of disease beginning mostly bilaterally as diffuse or patchy ground-glass opacity followed by progressive air-space consolidation. Also, a change in the CT morphology of pulmonary lesions toward diffuse ground-glass opacity seems to correlate with an unfavorable disease course.

Keywords: chest • cytomegalovirus pneumonia • diffuse alveolar damage • high-resolution CT • infectious diseases • transplantation


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